Structure of PDB 1zlh Chain A Binding Site BS01

Receptor Information

>1zlh Chain A (length=301) Species: 9913 (Bos taurus)

STNTFNYATYHTLDEIYDFMDLLVAEHPQLVSKLQIGRSYEGRPIYVLKF
STGGSNRPAIWIDLGIHSREWITQATGVWFAKKFTEDYGQDPSFTAILDS
MDIFLEIVTNPDGFAFTHSQNRLWRKTRSVTSLCVGVDANRNWDAGFGKA
GASSSPCSETYHGKYANSEVEVKSIVDFVKDHGNFKAFLSIHSYSQLLLY
PYGYTTQSIPDKTELNQVAKSAVAALKSLYGTSYKYGSIITTIYQASGGS
IDWSYNQGIKYSFTFELRDTGRYGFLLPASQIIPTAQETWLGVLTIMEHT
V

Ligand information

• Ligand ID: ZN
• InChI: InChI=1S/Zn/q+2
• InChIKey: PTFCDOFLOPIGGS-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Zn++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Zn+2]
• Formula: Zn
• Name: ZINC ION
• ChEMBL: CHEMBL1236970
• DrugBank: DB14532
• PDB chain: 1zlh Chain A Residue 555

Receptor-Ligand Complex Structure

Structure summary

• PDB: 1zlh The Three-Dimensional Structures of Tick Carboxypeptidase Inhibitor in Complex with A/B Carboxypeptidases Reveal a Novel Double-headed Binding Mode
• Resolution: 1.7 Å
• Binding residue (original residue number in PDB): H69 E72 H196
• Binding residue (residue number reindexed from 1): H67 E70 H192
• Annotation score: 1

Enzymatic activity

• Catalytic site (original residue number in PDB): H69 E72 R127 H196 E270
• Catalytic site (residue number reindexed from 1): H67 E70 R125 H192 E266
• Enzyme Commision number: 3.4.17.1: carboxypeptidase A.

Gene Ontology

Molecular Function

• GO:0004181 metallocarboxypeptidase activity
• GO:0008270 zinc ion binding

Biological Process

• GO:0006508 proteolysis

External links

• PDB: RCSB:1zlh, PDBe:1zlh, PDBj:1zlh
• PDBsum: 1zlh
• PubMed: 15961103
• UniProt: P00730|CBPA1_BOVIN Carboxypeptidase A1 (Gene Name=CPA1)