Structure of PDB 1zgv Chain A Binding Site BS01
Receptor Information
>1zgv Chain A (length=276) Species:
9606
(Homo sapiens) [
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DCGLRPLFEKKSLEDKTERELLESYIIVEGSDAEIGMSPWQVMLFRKSPQ
ELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDLLVRIGKHSRTRYERN
IEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDRE
TAASLLQAGYKGRVTGWGNLKEGQPSVLQVVNLPIVERPVCKDSTRIRIT
DNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCD
RDGKYGFYTHVFRLKKWIQKVIDQFG
Ligand information
>1zgv Chain B (length=10) Species:
6421
(Hirudo medicinalis) [
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DFEEIPEEYL
Receptor-Ligand Complex Structure
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PDB
1zgv
Development of an oxazolopyridine series of dual thrombin/factor Xa inhibitors via structure-guided lead optimization.
Resolution
2.2 Å
Binding residue
(original residue number in PDB)
F34 L40 R67 T74 R75 Y76 I82
Binding residue
(residue number reindexed from 1)
F45 L52 R88 T95 R96 Y97 I104
Enzymatic activity
Catalytic site (original residue number in PDB)
H57 D102 E192 G193 D194 S195 G196
Catalytic site (residue number reindexed from 1)
H69 D125 E220 G221 D222 S223 G224
Enzyme Commision number
3.4.21.5
: thrombin.
Gene Ontology
Molecular Function
GO:0004252
serine-type endopeptidase activity
GO:0005509
calcium ion binding
Biological Process
GO:0006508
proteolysis
GO:0007596
blood coagulation
Cellular Component
GO:0005576
extracellular region
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Biological Process
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Cellular Component
External links
PDB
RCSB:1zgv
,
PDBe:1zgv
,
PDBj:1zgv
PDBsum
1zgv
PubMed
16137886
UniProt
P00734
|THRB_HUMAN Prothrombin (Gene Name=F2)
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