Structure of PDB 1zet Chain A Binding Site BS01

Receptor Information
>1zet Chain A (length=388) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SRVIVHVDLDCFYAQVEMISNPELKDKPLGVQQKYLVVTCNYEARKLGVK
KLMNVRDAKEKCPQLVLVNGEDLTRYREMSYKVTELLEEFSPVVERLGFD
ENFVDLTEMVEKRLQQLQSDELSAVTVSGHVYNNQSINLLDVLHIRLLVG
SQIAAEMREAMYNQLGLTGCAGVASNKLLAKLVSGVFKPNQQTVLLPESC
QHLIHSLNHIKEIPGIGYKTAKCLEALGINSVRDLQTFSPKILEKELGIS
VAQRIQKLSFGEDNSPVILSGPPQSFSEEDSFKKCSSEVEAKNKIEELLA
SLLNRVCQDGRKPHTVRLIIRRYSSEKHYGRESRQCPIPSHVIQKLGTGN
YDVMTPMVDILMKLFRNMVNVKMPFHLTLLSVCFCNLK
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB1zet DNA polymerases: Hoogsteen base-pairing in DNA replication?
Resolution2.3 Å
Binding residue
(original residue number in PDB)		K60 E97 L99 R103 P299 Q300 S301 F302 S303 E304 E305 S307 K310
Binding residue
(residue number reindexed from 1)		K34 E71 L73 R77 P273 Q274 S275 F276 S277 E278 E279 S281 K284
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003684 damaged DNA binding
GO:0003887 DNA-directed DNA polymerase activity
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:1zet, PDBe:1zet, PDBj:1zet
PDBsum1zet
PubMed16163299
UniProtQ9UNA4|POLI_HUMAN DNA polymerase iota (Gene Name=POLI)

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