Structure of PDB 1ze2 Chain A Binding Site BS01

Receptor Information
>1ze2 Chain A (length=300) Species: 2336 (Thermotoga maritima) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MKHGILVAYKPKGPTSHDVVDEVRKKLKTRKVGHGGTLDPFACGVLIIGV
NQGTRILEFYKDLKKVYWVKMRLGLITETFDITGEVVEERECNVTEEEIR
EAIFSFVGEYDQVPPAYSAKKYKGERLYKLAREGKIINLPPKRVKIFKIW
DVNIEGRDVSFRVEVSPGTYIRSLCMDIGYKLGCGATAVELVRESVGPHT
IEESLNVFEAAPEEIENRIIPLEKCLEWLPRVVVHQESTKMILNGSQIHL
EMLKEWDGFKKGEVVRVFNEEGRLLALAEAERNSSFRQERVLTLRKVFQT
Ligand information
>1ze2 Chain C (length=22) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ggccacgguucgaauccguggc
.<<<<<<<.......>>>>>>>
Receptor-Ligand Complex Structure
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PDB1ze2 Conformational change of pseudouridine 55 synthase upon its association with RNA substrate
Resolution3.0 Å
Binding residue
(original residue number in PDB)		T15 H17 R24 K31 V32 G33 H34 G36 T37 L38 D39 P40 T54 E58 Y67 T79 D81 Y117 S118 A119 K120 K121 Y122 K123 G124 R126 Y128 R132 Y170 I171 R172 L191 K304
Binding residue
(residue number reindexed from 1)		T15 H17 R24 K31 V32 G33 H34 G36 T37 L38 D39 P40 T54 E58 Y67 T79 D81 Y117 S118 A119 K120 K121 Y122 K123 G124 R126 Y128 R132 Y170 I171 R172 L191 K296
Enzymatic activity
Enzyme Commision number 5.4.99.25: tRNA pseudouridine(55) synthase.
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0009982 pseudouridine synthase activity
GO:0016853 isomerase activity
GO:0140098 catalytic activity, acting on RNA
GO:0160148 tRNA pseudouridine(55) synthase activity
Biological Process
GO:0001522 pseudouridine synthesis
GO:0006396 RNA processing
GO:0006400 tRNA modification
GO:0008033 tRNA processing
GO:0009451 RNA modification
GO:0031119 tRNA pseudouridine synthesis
GO:1990481 mRNA pseudouridine synthesis

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Molecular Function
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Biological Process
External links
PDB RCSB:1ze2, PDBe:1ze2, PDBj:1ze2
PDBsum1ze2
PubMed14990747
UniProtQ9WZW0|TRUB_THEMA tRNA pseudouridine synthase B (Gene Name=truB)

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