Structure of PDB 1zdw Chain A Binding Site BS01

Receptor Information
>1zdw Chain A (length=301) Species: 93372 (Streptomyces sp. CL190) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EAADVERVYAAMEEAAGLLGVACARDKIYPLLSTFQDTLVEGGSVVVFSM
ASGRHSTELDFSISVPTSHGDPYATVVEKGLFPATGHPVDDLLADTQKHL
PVSMFAIDGEVTGGFKKTYAFFPTDNMPGVAELSAIPSMPPAVAENAELF
ARYGLDKVQMTSMDYKKRQVNLYFSELSAQTLEAESVLALVRELGLHVPN
ELGLKFCKRSFSVYPTLNWETGKIDRLCFAVISNDPTLVPSSDEGDIEKF
HNYATKAPYAYVGEKRTLVYGLTLSPKEEYYKLGAYYHITDVQRGLLKAF
D
Ligand information
Ligand IDFLV
InChIInChI=1S/C10H6O5/c11-4-1-5-9(6(12)2-4)7(13)3-8(14)10(5)15/h1-3,11-12,14H
InChIKeyRROPNRTUMVVUED-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341Oc1cc(O)c2C(=O)C=C(O)C(=O)c2c1
ACDLabs 10.04O=C2c1c(O)cc(O)cc1C(=O)C(O)=C2
OpenEye OEToolkits 1.5.0c1c(cc(c2c1C(=O)C(=CC2=O)O)O)O
FormulaC10 H6 O5
NameFLAVIOLIN;
2,5,7-TRIHYDROXYNAPHTHOQUINONE
ChEMBLCHEMBL1232770
DrugBankDB02521
ZINC
PDB chain1zdw Chain A Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB1zdw Structural basis for the promiscuous biosynthetic prenylation of aromatic natural products.
Resolution2.02 Å
Binding residue
(original residue number in PDB)		Q161 M162 Y175 F213 S214 Y288 Q295 L298
Binding residue
(residue number reindexed from 1)		Q159 M160 Y173 F211 S212 Y286 Q293 L296
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0004659 prenyltransferase activity
GO:0016740 transferase activity
GO:0046872 metal ion binding

View graph for
Molecular Function
External links
PDB RCSB:1zdw, PDBe:1zdw, PDBj:1zdw
PDBsum1zdw
PubMed15959519
UniProtQ4R2T2

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