Structure of PDB 1zco Chain A Binding Site BS01

Receptor Information
>1zco Chain A (length=262) Species: 2261 (Pyrococcus furiosus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MKYSKEYDEKTVVKINDVKFGEGFTIIAGPCSIESREQIMKVAEFLAEVG
IKVLRGGAFKPRTSPYSFQGYGEKALRWMREAADEYGLVTVTEVMDTRHV
ELVAKYSDILQIGARNSQNFELLKEVGKVENPVLLKRGMGNTIQELLYSA
EYIMAQGNENVILCERGIRTFETATRFTLDISAVPVVKELSHLPIIVDPS
HPAGRRSLVIPLAKAAYAIGADGIMVEVHPEPEKALSDSQQQLTFDDFLQ
LLKELEALGWKG
Ligand information
Ligand IDPEP
InChIInChI=1S/C3H5O6P/c1-2(3(4)5)9-10(6,7)8/h1H2,(H,4,5)(H2,6,7,8)
InChIKeyDTBNBXWJWCWCIK-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0C=C(C(=O)O)OP(=O)(O)O
CACTVS 3.341OC(=O)C(=C)O[P](O)(O)=O
ACDLabs 10.04O=C(O)C(\OP(=O)(O)O)=C
FormulaC3 H5 O6 P
NamePHOSPHOENOLPYRUVATE
ChEMBLCHEMBL1235228
DrugBankDB01819
ZINCZINC000003870145
PDB chain1zco Chain A Residue 901 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1zco Substrate Ambiguity and Crystal Structure of Pyrococcus furiosus 3-Deoxy-d-arabino-heptulosonate-7-phosphate Synthase: An Ancestral 3-Deoxyald-2-ulosonate-phosphate Synthase?(,)
Resolution2.25 Å
Binding residue
(original residue number in PDB)		R55 Q111 G113 A114 K136 R166 H201
Binding residue
(residue number reindexed from 1)		R55 Q111 G113 A114 K136 R166 H201
Annotation score5
Enzymatic activity
Enzyme Commision number 2.5.1.54: 3-deoxy-7-phosphoheptulonate synthase.
Gene Ontology
Molecular Function
GO:0003849 3-deoxy-7-phosphoheptulonate synthase activity
GO:0016740 transferase activity
GO:0016832 aldehyde-lyase activity
GO:0046872 metal ion binding
Biological Process
GO:0009058 biosynthetic process
GO:0009073 aromatic amino acid family biosynthetic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:1zco, PDBe:1zco, PDBj:1zco
PDBsum1zco
PubMed16142893
UniProtQ8U0A9

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