Structure of PDB 1zc0 Chain A Binding Site BS01

Receptor Information

>1zc0 Chain A (length=286) Species: 9606 (Homo sapiens)

TPREVTLHFLRTAGHPLTRWALQRQPPSPKQLEEEFLKIPSNFVSPEDLD
IPGHASKDRYKTILPNPQSRVCLGRAQSQEDGDYINANYIRGYDGKEKVY
IATQGPMPNTVSDFWEMVWQEEVSLIVMLTQLRECVHYWPTEEETYGPFQ
IRIQDMKECPEYTVRQLTIQYQEERRSVKHILFSAWPDHQTPESAGPLLR
LVAEVEESPETAAHPGPIVVHCSAGIGRTGCFIATRIGCQQLKARGEVDI
LGIVCQLRLDRGGMIQTAEQYQFLHHTLALYAGQLP

Ligand information

• Ligand ID: PO4
• InChI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-3
• InChIKey: NBIIXXVUZAFLBC-UHFFFAOYSA-K
• SMILES:
  CACTVS 3.341: [O-][P]([O-])([O-])=O
  ACDLabs 10.04: [O-]P([O-])([O-])=O
  OpenEye OEToolkits 1.5.0: [O-]P(=O)([O-])[O-]
• Formula: O4 P
• Name: PHOSPHATE ION
• DrugBank: DB14523
• PDB chain: 1zc0 Chain A Residue 436

Receptor-Ligand Complex Structure

Structure summary

• PDB: 1zc0 Structure of the hematopoietic tyrosine phosphatase (HePTP) catalytic domain: structure of a KIM phosphatase with phosphate bound at the active site.
• Resolution: 1.85 Å
• Binding residue (original residue number in PDB): D236 C270 S271 A272 I274 G275 R276 Q314
• Binding residue (residue number reindexed from 1): D188 C222 S223 A224 I226 G227 R228 Q266
• Annotation score: 1

Enzymatic activity

• Catalytic site (original residue number in PDB): D236 C270 R276 T277 Q314
• Catalytic site (residue number reindexed from 1): D188 C222 R228 T229 Q266
• Enzyme Commision number: 3.1.3.48: protein-tyrosine-phosphatase.

Gene Ontology

Molecular Function

• GO:0004725 protein tyrosine phosphatase activity

Biological Process

• GO:0006470 protein dephosphorylation
• GO:0016311 dephosphorylation

External links

• PDB: RCSB:1zc0, PDBe:1zc0, PDBj:1zc0
• PDBsum: 1zc0
• PubMed: 16226275
• UniProt: P35236|PTN7_HUMAN Tyrosine-protein phosphatase non-receptor type 7 (Gene Name=PTPN7)