Structure of PDB 1zb7 Chain A Binding Site BS01

Receptor Information
>1zb7 Chain A (length=414) Species: 1491 (Clostridium botulinum) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PVNIKNFNYNDPINNDDIIMMEPFNDPGPGTYYKAFRIIDRIWIVPERFT
YKDVYEYYDPTYLKTDAEKDKFLKTMIKLFNRINSKPSGQRLLDMIVDAI
PYLGNASTPPDKFAANVANVSINKKIIQPGAEDQIKGLMTNLIIFGPGPV
LSDNFTDSMIMNGHSPISEGFGARMMIRFCPSCLNVFNNVQENKIFSRRA
YFADPALTLMHELIHVLHGLYGIKISNLPITPFMQHSDPVQAEELYTFGG
HDPSVISPSTDMNIYNKALQNFQDIANRLNIVSSAQGSGIDISLYKQIYK
NKYDFVEDPNGKYSVDKDKFDKLYKALMFGFTETNLAGEYGIKTRYSYFS
EYLPPIKTEKLLDNTIYTQNEGFNIASKNLKTEFNGQNKAVNKEAYEEIS
LEHLVIYRIAMCKP
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain1zb7 Chain A Residue 500 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB1zb7 Crystal structure of botulinum neurotoxin type g light chain: serotype divergence in substrate recognition
Resolution2.35 Å
Binding residue
(original residue number in PDB)		H230 H234
Binding residue
(residue number reindexed from 1)		H211 H215
Annotation score4
Enzymatic activity
Catalytic site (original residue number in PDB) H230 E231 H234 E268 R369
Catalytic site (residue number reindexed from 1) H211 E212 H215 E244 R345
Enzyme Commision number 3.4.24.69: bontoxilysin.
Gene Ontology
Molecular Function
GO:0004222 metalloendopeptidase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:1zb7, PDBe:1zb7, PDBj:1zb7
PDBsum1zb7
PubMed16008342
UniProtQ60393|BXG_CLOBO Botulinum neurotoxin type G (Gene Name=botG)

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