Structure of PDB 1zar Chain A Binding Site BS01

Receptor Information
>1zar Chain A (length=267) Species: 2234 (Archaeoglobus fulgidus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NIAELYGKMGKHSWRIMDAIFKNLWDYEYVPLQLISSHARIGEEKARNIL
KYLSDLRVVQNRQKDYEGSTFTFIGLSLYSLHRLVRSGKVDAIGKLMGEG
KESAVFNCYSEKFGECVVKFHKVKVKEHFSVLAIRSARNEFRALQKLQGL
AVPKVYAWEGNAVLMELIDAKELYRVRVENPDEVLDMILEEVAKFYHRGI
VHGDLSQYNVLVSEEGIWIIDFPQSVEVGEEGWREILERDVRNIITYFSR
TYRTEKDINSAIDRILQ
Ligand information
Ligand IDMN
InChIInChI=1S/Mn/q+2
InChIKeyWAEMQWOKJMHJLA-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mn+2]
CACTVS 3.341[Mn++]
FormulaMn
NameMANGANESE (II) ION
ChEMBL
DrugBankDB06757
ZINC
PDB chain1zar Chain A Residue 402 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1zar Autophosphorylation of Archaeoglobus fulgidus Rio2 and crystal structures of its nucleotide-metal ion complexes.
Resolution1.75 Å
Binding residue
(original residue number in PDB)		N223 D235
Binding residue
(residue number reindexed from 1)		N209 D221
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0044024 histone H2AS1 kinase activity
GO:0046872 metal ion binding
GO:0106310 protein serine kinase activity
Biological Process
GO:0006338 chromatin remodeling
GO:0006468 protein phosphorylation
GO:0016310 phosphorylation
GO:0030490 maturation of SSU-rRNA
Cellular Component
GO:0005829 cytosol
GO:0030688 preribosome, small subunit precursor

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1zar, PDBe:1zar, PDBj:1zar
PDBsum1zar
PubMed15943813
UniProtO30245|RIO2_ARCFU RIO-type serine/threonine-protein kinase Rio2 (Gene Name=rio2)

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