Structure of PDB 1zao Chain A Binding Site BS01

Receptor Information

>1zao Chain A (length=271) Species: 2234 (Archaeoglobus fulgidus)

MNIAELYGKMGKHSWRIMDAIFKNLWDYEYVPLQLISSHARIGEEKARNI
LKYLSDLRVVQNRQKDYEGSTFTFIGLSLYSLHRLVRSGKVDAIGKLMGE
GKESAVFNCYSEKFGECVVKFHKVGHTKVKEFSVLAIRSARNEFRALQKL
QGLAVPKVYAWEGNAVLMELIDAKELYRVRVENPDEVLDMILEEVAKFYH
RGIVHGDLSQYNVLVSEEGIWIIDFPQSVEVGEEGWREILERDVRNIITY
FSRTYRTEKDINSAIDRILQE

Ligand information

• Ligand ID: MN
• InChI: InChI=1S/Mn/q+2
• InChIKey: WAEMQWOKJMHJLA-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mn+2]
  CACTVS 3.341: [Mn++]
• Formula: Mn
• Name: MANGANESE (II) ION
• DrugBank: DB06757
• PDB chain: 1zao Chain A Residue 283

Receptor-Ligand Complex Structure

Structure summary

• PDB: 1zao Autophosphorylation of Archaeoglobus fulgidus Rio2 and crystal structures of its nucleotide-metal ion complexes.
• Resolution: 1.84 Å
• Binding residue (original residue number in PDB): N223 D235
• Binding residue (residue number reindexed from 1): N212 D224
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 2.7.11.1: non-specific serine/threonine protein kinase.

Gene Ontology

Molecular Function

• GO:0004672 protein kinase activity
• GO:0004674 protein serine/threonine kinase activity
• GO:0005524 ATP binding
• GO:0044024 histone H2AS1 kinase activity
• GO:0046872 metal ion binding
• GO:0106310 protein serine kinase activity

Biological Process

• GO:0006338 chromatin remodeling
• GO:0006468 protein phosphorylation
• GO:0016310 phosphorylation
• GO:0030490 maturation of SSU-rRNA

Cellular Component

• GO:0005829 cytosol
• GO:0030688 preribosome, small subunit precursor

External links

• PDB: RCSB:1zao, PDBe:1zao, PDBj:1zao
• PDBsum: 1zao
• PubMed: 15943813
• UniProt: O30245|RIO2_ARCFU RIO-type serine/threonine-protein kinase Rio2 (Gene Name=rio2)