Structure of PDB 1z7y Chain A Binding Site BS01

Receptor Information
>1z7y Chain A (length=320) Species: 3702 (Arabidopsis thaliana) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SRIAKDVTELIGNTPLVYLNNVAEGCVGRVAAKLEMMEPCSSVADRIGFS
MISDAEKKGLIKPGESVLIEPTSGNTGVGLAFTAAAKGYKLIITMPASMS
TERRIILLAFGVELVLTDPAKGMKGAIAKAEEILAKTPNGYMLQQFENPA
NPKIHYETTGPEIWKGTGGKIDGFVSGIGTGGTITGAGKYLKEQNANVKL
YGVEPVESAILSGGKPGPHKIQGIGAGFIPSVLNVDLIDEVVQVSSDESI
DMARQLALKEGLLVGISSGAAAAAAIKLAQRPENAGKLFVAIFPSFGERY
LSTVLFDATRKEAEAMTFEA
Ligand information
Ligand IDAA5
InChIInChI=1S/C13H19N2O7PS/c1-8-12(16)10(6-15-11(13(17)18)3-4-24-2)9(5-14-8)7-22-23(19,20)21/h5-6,11,16H,3-4,7H2,1-2H3,(H,17,18)(H2,19,20,21)/b15-6+/t11-/m0/s1
InChIKeyHPCOPQVFKQIVQF-DMSFABOWSA-N
SMILES
SoftwareSMILES
CACTVS 3.341CSCC[CH](N=Cc1c(O)c(C)ncc1CO[P](O)(O)=O)C(O)=O
ACDLabs 10.04O=C(O)C(/N=C/c1c(cnc(c1O)C)COP(=O)(O)O)CCSC
OpenEye OEToolkits 1.5.0Cc1c(c(c(cn1)COP(=O)(O)O)C=NC(CCSC)C(=O)O)O
OpenEye OEToolkits 1.5.0Cc1c(c(c(cn1)COP(=O)(O)O)C=N[C@@H](CCSC)C(=O)O)O
CACTVS 3.341CSCC[C@H](N=Cc1c(O)c(C)ncc1CO[P](O)(O)=O)C(O)=O
FormulaC13 H19 N2 O7 P S
NameN-[(3-HYDROXY-2-METHYL-5-{[(TRIHYDROXYPHOSPHORANYL)OXY]METHYL}PYRIDIN-4-YL)METHYLENE]METHIONINE
ChEMBL
DrugBank
ZINCZINC000033360256
PDB chain1z7y Chain A Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB1z7y Molecular Basis of Cysteine Biosynthesis in Plants: STRUCTURAL AND FUNCTIONAL ANALYSIS OF O-ACETYLSERINE SULFHYDRYLASE FROM ARABIDOPSIS THALIANA.
Resolution2.7 Å
Binding residue
(original residue number in PDB)		G76 N77 T78 Q147 I180 G181 T182 G183 T185 G225 S269 P296 S297
Binding residue
(residue number reindexed from 1)		G74 N75 T76 Q145 I178 G179 T180 G181 T183 G223 S267 P294 S295
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) A46 S269
Catalytic site (residue number reindexed from 1) A44 S267
Enzyme Commision number 2.5.1.47: cysteine synthase.
Gene Ontology
Molecular Function
GO:0003729 mRNA binding
GO:0004124 cysteine synthase activity
GO:0005515 protein binding
GO:0016740 transferase activity
Biological Process
GO:0006535 cysteine biosynthetic process from serine
GO:0009567 double fertilization forming a zygote and endosperm
GO:0009860 pollen tube growth
GO:0019344 cysteine biosynthetic process
GO:0046686 response to cadmium ion
Cellular Component
GO:0000325 plant-type vacuole
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005777 peroxisome
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0009507 chloroplast
GO:0009570 chloroplast stroma
GO:0048046 apoplast

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:1z7y, PDBe:1z7y, PDBj:1z7y
PDBsum1z7y
PubMed16166087
UniProtP47998|CYSK1_ARATH Cysteine synthase 1 (Gene Name=OASA1)

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