Structure of PDB 1z6y Chain A Binding Site BS01

Receptor Information
>1z6y Chain A (length=169) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ILFTRIWRLFNHQEHKVIIVGLDNAGKTTILYQFSMNEVVHTSPTIGSNV
EEIVINNTRFLMWDIGGQESLRSYYTNTEFVIVVVDSTDRERISVTREEL
YKMLAHEDLRKAGLLIFANKQDVKECMTVAEISQFLKLTSIKDHQWHIQA
CCALTGEGLCQGLEWMMSR
Ligand information
Ligand IDGDP
InChIInChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/t3-,5-,6-,9-/m1/s1
InChIKeyQGWNDRXFNXRZMB-UUOKFMHZSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.7.6c1nc2c(n1C3C(C(C(O3)COP(=O)(O)OP(=O)(O)O)O)O)N=C(NC2=O)N
CACTVS 3.385NC1=Nc2n(cnc2C(=O)N1)[C@@H]3O[C@H](CO[P](O)(=O)O[P](O)(O)=O)[C@@H](O)[C@H]3O
CACTVS 3.385NC1=Nc2n(cnc2C(=O)N1)[CH]3O[CH](CO[P](O)(=O)O[P](O)(O)=O)[CH](O)[CH]3O
ACDLabs 12.01O=P(O)(O)OP(=O)(O)OCC3OC(n2cnc1c2N=C(N)NC1=O)C(O)C3O
OpenEye OEToolkits 1.7.6c1nc2c(n1[C@H]3[C@@H]([C@@H]([C@H](O3)CO[P@](=O)(O)OP(=O)(O)O)O)O)N=C(NC2=O)N
FormulaC10 H15 N5 O11 P2
NameGUANOSINE-5'-DIPHOSPHATE
ChEMBLCHEMBL384759
DrugBankDB04315
ZINCZINC000008215481
PDB chain1z6y Chain A Residue 180 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1z6y Structure Of Human ADP-Ribosylation Factor-Like 5
Resolution2.4 Å
Binding residue
(original residue number in PDB)		N26 G28 K29 T30 T31 N125 K126 D128 C158 A159 L160
Binding residue
(residue number reindexed from 1)		N24 G26 K27 T28 T29 N119 K120 D122 C152 A153 L154
Annotation score4
Enzymatic activity
Catalytic site (original residue number in PDB) Q70
Catalytic site (residue number reindexed from 1) Q68
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0006886 intracellular protein transport
GO:0016192 vesicle-mediated transport
GO:1903292 protein localization to Golgi membrane
Cellular Component
GO:0005802 trans-Golgi network

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1z6y, PDBe:1z6y, PDBj:1z6y
PDBsum1z6y
PubMed
UniProtQ9Y689|ARL5A_HUMAN ADP-ribosylation factor-like protein 5A (Gene Name=ARL5A)

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