Structure of PDB 1z50 Chain A Binding Site BS01

Receptor Information
>1z50 Chain A (length=448) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
INDNRYINGINQFYFSIAEGRNLTLGPLLNMPSFIPTATTPEGCTRIPSF
SLTKTHWCYTHNVILNGCQDHVSSNQFVSMGIIEPTSAGFPFFRTLKTLY
LSDGVNRKSCSISTVPGGCMMYCFVSTQPERDDYFSAAPPEQRIIIMYYN
DTIVERIINPPGVLDVWATLNPGTGSGVYYLGWVLFPIYGGVIKGTSLWN
NQANKYFIPQMVAALCSQNQATQVQNAKSSYYSSWFGNRMIQSGILACPL
RQDLTNECLVLPFSNDQVLMGAEGRLYMYGDSVYYYQRSNSWWPMTMLYK
VTITFTNGQPSAISAQNVPTQQVPRPGTGDCSATNRCPGFCLTGVYADAW
LLTNPSSTSTFGSEATFTGSYLNTATQRINPTMYIANNTQIISSQQFGSS
GQEAAYGHTTCFRDTGSVMVYCIYIIELSSSLLGQFQIVPFIRQVTLS
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain1z50 Chain A Residue 600 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1z50 Structural studies of the parainfluenza virus 5 hemagglutinin-neuraminidase tetramer in complex with its receptor, sialyllactose.
Resolution2.8 Å
Binding residue
(original residue number in PDB)		D250 S253 A255 P256 A285
Binding residue
(residue number reindexed from 1)		D133 S136 A138 P139 A168
Annotation score4
Enzymatic activity
Enzyme Commision number 3.2.1.18: exo-alpha-sialidase.
Gene Ontology
Molecular Function
GO:0004308 exo-alpha-sialidase activity
GO:0016787 hydrolase activity
GO:0042802 identical protein binding
GO:0046789 host cell surface receptor binding
Biological Process
GO:0019058 viral life cycle
GO:0019062 virion attachment to host cell
GO:0046718 symbiont entry into host cell
GO:0046761 viral budding from plasma membrane
Cellular Component
GO:0016020 membrane
GO:0019031 viral envelope
GO:0020002 host cell plasma membrane
GO:0055036 virion membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1z50, PDBe:1z50, PDBj:1z50
PDBsum1z50
PubMed15893670
UniProtP04850|HN_PIV5 Hemagglutinin-neuraminidase (Gene Name=HN)

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