Structure of PDB 1z3h Chain A Binding Site BS01

Receptor Information
>1z3h Chain A (length=925) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SDLETVAKFLAESVIASTAKTSERNLRQLETQDGFGLTLLHVIASTNLPL
STRLAGALFFKNFIKRKWVDENGNHLLPANNVELIKKEIVPLMISLPNNL
QVQIGEAISSIADSDFPDRWPTLLSDLASRLSNDDMVTNKGVLTVAHSIF
KRWRPLFRSDELFLEIKLVLDVFTAPFLNLLKTVDEQITANENNKASLNI
LFDVLLVLIKLYYDFNCQDIPEFFEDNIQVGMGIFHKYLSYSNPLLEDPD
ETEHASVLIKVKSSIQELVQLYTTRYEDVFGPMINEFIQITWNLLTSISN
QPKYDILVSKSLSFLTAVTRIPKYFEIFNNESAMNNITEQIILPNVTLRE
EDVELFEDDPIEYIRRDLEGSDTDTRRRACTDFLKELKEKNEVLVTNIFL
AHMKGFVDQYMSDPSKNWKFKDLYIYLFTALAINGNITNAGVSSTNNLLN
VVDFFTKEIAPDLTSNNIPHIILRVDAIKYIYTFRNQLTKAQLIELMPIL
ATFLQTDEYVVYTYAAITIEKILTIRESSNSTEILLKNLIALILKHGSSP
EKLAENEFLMRSIFRVLQTSEDSIQPLFPQLLAQFIEIVTIMAKNPSNPR
FTHYTFESIGAILNYTQRQNLPLLVDSMMPTFLTVFSEDIQEFIPYVFQI
IAFVVEQSATIPESIKPLAQPLLAPNVWELKGNIPAVTRLLKSFIKTDSS
IFPDLVPVLGIFQRLIASKAYEVHGFDLLEHIMLLIDMNRLRPYIKQIAV
LLLQRLQNSKTERYVKKLTVFFGLISNKLGSDFLIHFIDEVQDGLFQQIW
GNFIITTLPTIGNLLDRKIALIGVLNMVINGQFFQSKYPTLISSTMNSII
ETASSQSGSHFSKLVSISEKPFDPLPEIDVNNGVRLYVAEALNKYNAISG
NTFLNTILPQLTQENQVKLNQLLVG
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain1z3h Chain A Residue 969 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB1z3h The structure of the nuclear export receptor cse1 in its cytosolic state reveals a closed conformation incompatible with cargo binding
Resolution3.1 Å
Binding residue
(original residue number in PDB)		D796 H800
Binding residue
(residue number reindexed from 1)		D782 H786
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005049 nuclear export signal receptor activity
GO:0005515 protein binding
GO:0031267 small GTPase binding
Biological Process
GO:0006606 protein import into nucleus
GO:0006611 protein export from nucleus
GO:0006886 intracellular protein transport
GO:0015031 protein transport
GO:0046827 positive regulation of protein export from nucleus
GO:0051170 import into nucleus
GO:0051301 cell division
GO:0061015 snRNA import into nucleus
Cellular Component
GO:0005634 nucleus
GO:0005635 nuclear envelope
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0032991 protein-containing complex

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:1z3h, PDBe:1z3h, PDBj:1z3h
PDBsum1z3h
PubMed15866177
UniProtP33307|CSE1_YEAST Importin alpha re-exporter (Gene Name=CSE1)

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