Structure of PDB 1z2m Chain A Binding Site BS01

Receptor Information
>1z2m Chain A (length=152) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
WDLTVKMLAGNEFQVSLSSSMSVSELKAQITQKIGVHAFQQRLAVHPSGV
ALQDRVPLASQGLGPGSTVLLVVDKSDEPLSILVRNNKGRSSTYEVRLTQ
TVAHLKQQVSGLEGVQDDLFWLTFEGKPLEDQLPLGEYGLKPLSTVFMNL
RL
Ligand information
Ligand IDOS4
InChIInChI=1S/Os/q+4
InChIKeyOQURWADGXKZUIH-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 12.01
CACTVS 3.370
OpenEye OEToolkits 1.7.2		[Os+4]
FormulaOs
NameOSMIUM 4+ ION
ChEMBL
DrugBank
ZINC
PDB chain1z2m Chain A Residue 400 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1z2m Crystal Structure of the Interferon-induced Ubiquitin-like Protein ISG15.
Resolution2.5 Å
Binding residue
(original residue number in PDB)		G12 N13
Binding residue
(residue number reindexed from 1)		G10 N11
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005178 integrin binding
GO:0005515 protein binding
GO:0031386 protein tag activity
GO:0031625 ubiquitin protein ligase binding
Biological Process
GO:0007229 integrin-mediated signaling pathway
GO:0009615 response to virus
GO:0009617 response to bacterium
GO:0016567 protein ubiquitination
GO:0019941 modification-dependent protein catabolic process
GO:0030501 positive regulation of bone mineralization
GO:0031397 negative regulation of protein ubiquitination
GO:0032020 ISG15-protein conjugation
GO:0032461 positive regulation of protein oligomerization
GO:0032649 regulation of type II interferon production
GO:0032728 positive regulation of interferon-beta production
GO:0032729 positive regulation of type II interferon production
GO:0032733 positive regulation of interleukin-10 production
GO:0034340 response to type I interferon
GO:0042742 defense response to bacterium
GO:0045071 negative regulation of viral genome replication
GO:0045087 innate immune response
GO:0045648 positive regulation of erythrocyte differentiation
GO:0051607 defense response to virus
GO:0060339 negative regulation of type I interferon-mediated signaling pathway
GO:0070585 protein localization to mitochondrion
Cellular Component
GO:0005576 extracellular region
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1z2m, PDBe:1z2m, PDBj:1z2m
PDBsum1z2m
PubMed15917233
UniProtP05161|ISG15_HUMAN Ubiquitin-like protein ISG15 (Gene Name=ISG15)

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