Structure of PDB 1z25 Chain A Binding Site BS01

Receptor Information
>1z25 Chain A (length=713) Species: 2261 (Pyrococcus furiosus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SMKAIVVINLVKINKKIIPDKIYVYRLYSIYRLAYENVGIVIDPENLIIA
TTKELEYEGEFIPEGEISFSELRNDYQSKLVLRLLKENGIGEYELSKLLR
KFRKPKTFGDYKVIPSVEMSVIKHDEDFYLVIHIIHQIQSMKTLWELVNK
DPKELEEFLMTHKENLMLKDIASPLKTVYKPCFEEYTKKPKLDHNQEIVK
YWYNYHIERYWNTPEAKLEFYRKFGQVDLKQPAILAKFASKNYKIYLLPQ
LVVPTYNAEQLAKEILEYTKLMPEERKELLENILAEVDSDIIDKSLSEIE
VEKIAQELENKIRVRDDKGNSVPISQLLWTNYSRKYPVILPYEVPEKFRK
IREIPMFIILDSGLLADIQNFATNEFRELVKSMYYEKVITEDLNSDKGII
EVVEQVSSFMKGKELGLAFIAARNKLSSEKFEEIKRRLFNLNVISQVVNE
DTLKNKRDKYDRNRLDLFVRHNLLFQVLSKLGVKYYVLDYRFNYDYIIGI
DVAPMKRSEGYIGGSAVMFDSQGYIRKIVPIKIGEQRGESVDMNEFFKEM
VDKFKEFNIKLDNKKILLLRDGRITNNEEEGLKYISEMFDIEVVTMDVIK
NHPVRAFANMKMYFNLGGAIYLIPHKLKQAKGTPIPIKLAKKRIIKNGKV
EKQSITRQDVLDIFILTRLNYGSISADMRLPAPVHYAHKFANAIRNEWKI
KEEFLAEGFLYFV
Ligand information
Ligand IDMN
InChIInChI=1S/Mn/q+2
InChIKeyWAEMQWOKJMHJLA-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mn+2]
CACTVS 3.341[Mn++]
FormulaMn
NameMANGANESE (II) ION
ChEMBL
DrugBankDB06757
ZINC
PDB chain1z25 Chain A Residue 771 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB1z25 Purified Argonaute2 and an siRNA form recombinant human RISC.
Resolution2.7 Å
Binding residue
(original residue number in PDB)		D558 D628 H745
Binding residue
(residue number reindexed from 1)		D501 D571 H688
Annotation score4
Enzymatic activity
Enzyme Commision number 3.1.24.-
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0004519 endonuclease activity
GO:0004520 DNA endonuclease activity
GO:0030145 manganese ion binding
GO:0046872 metal ion binding
Biological Process
GO:0006259 DNA metabolic process
GO:0044355 clearance of foreign intracellular DNA

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Molecular Function
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Biological Process
External links
PDB RCSB:1z25, PDBe:1z25, PDBj:1z25
PDBsum1z25
PubMed15800637
UniProtQ8U3D2|AGO_PYRFU Protein argonaute (Gene Name=ago)

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