Structure of PDB 1yu9 Chain A Binding Site BS01

Receptor Information
>1yu9 Chain A (length=175) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GPLGSETYDFLFKFLVIGNAGTGKSCLLHQFIEKKFKDDSNHTIGVEFGS
KIINVGGKYVKLQIWDTAGQERFRSVTRSYYRGAAGALLVYDITSRETYN
ALTNWLTDARMLASQNIVIILCGNKKDLDADREVTFLEASRFAQENELMF
LETSALTGEDVEEAFVQCARKILNK
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain1yu9 Chain A Residue 701 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB1yu9 Structural basis of family-wide Rab GTPase recognition by rabenosyn-5.
Resolution2.07 Å
Binding residue
(original residue number in PDB)		S22 T40
Binding residue
(residue number reindexed from 1)		S25 T43
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) Q67
Catalytic site (residue number reindexed from 1) Q70
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0032482 Rab protein signal transduction

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Molecular Function
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Biological Process
External links
PDB RCSB:1yu9, PDBe:1yu9, PDBj:1yu9
PDBsum1yu9
PubMed16034420
UniProtP20338|RAB4A_HUMAN Ras-related protein Rab-4A (Gene Name=RAB4A)

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