Structure of PDB 1ytw Chain A Binding Site BS01

Receptor Information

>1ytw Chain A (length=283) Species: 630 (Yersinia enterocolitica)

VSPYGPEARAELSSRLTTLRNTLAPATNDPRYLQACGGEKLNRFRDIQCR
RQTAVRADLNANYIQVGNTRTIACQYPLQSQLESHFRMLAENRTPVLAVL
ASSSEIANQRFGMPDYFRQSGTYGSITVESKMTQQVGLGDGIMADMYTLT
IREAGQKTISVPVVHVGNWPDQTAVSSEVTKALASLVDQTAETKRNMYES
KGSSAVADDSKLRPVIHCRAGVGRTAQLIGAMCMNDSRNSQLSVEDMVSQ
MRVQRNGIMVQKDEQLDVLIKLAEGQGRPLLNS

Ligand information

• Ligand ID: WO4
• InChI: InChI=1S/4O.W/q;;2*-1;
• InChIKey: PBYZMCDFOULPGH-UHFFFAOYSA-N
• SMILES:
  OpenEye OEToolkits 1.5.0: [O-][W](=O)(=O)[O-]
  ACDLabs 10.04
  CACTVS 3.341: [O-][W]([O-])(=O)=O
• Formula: O4 W
• Name: TUNGSTATE(VI)ION
• PDB chain: 1ytw Chain A Residue 1

Receptor-Ligand Complex Structure

Structure summary

• PDB: 1ytw The X-ray crystal structures of Yersinia tyrosine phosphatase with bound tungstate and nitrate. Mechanistic implications.
• Resolution: 2.4 Å
• Binding residue (original residue number in PDB): D356 C403 R404 A405 V407 G408 R409 Q446
• Binding residue (residue number reindexed from 1): D171 C218 R219 A220 V222 G223 R224 Q261
• Annotation score: 1

Enzymatic activity

• Catalytic site (original residue number in PDB): E290 W354 D356 H402 C403 R409 T410
• Catalytic site (residue number reindexed from 1): E105 W169 D171 H217 C218 R224 T225
• Enzyme Commision number: 3.1.3.48: protein-tyrosine-phosphatase.

Gene Ontology

Molecular Function

• GO:0004725 protein tyrosine phosphatase activity

Biological Process

• GO:0006470 protein dephosphorylation
• GO:0016311 dephosphorylation

External links

• PDB: RCSB:1ytw, PDBe:1ytw, PDBj:1ytw
• PDBsum: 1ytw
• PubMed: 8702535
• UniProt: P15273|YOPH_YEREN Tyrosine-protein phosphatase YopH (Gene Name=yopH)