Structure of PDB 1yts Chain A Binding Site BS01

Receptor Information
>1yts Chain A (length=278) Species: 630 (Yersinia enterocolitica) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PEARAELSSRLTTLRNTLAPATNDPRYLQACGGEKLNRFRDIQCRRQTAV
RADLNANYIQVGNTRTIACQYPLQSQLESHFRMLAENRTPVLAVLASSSE
IANQRFGMPDYFRQSGTYGSITVESKMTQQVGLGDGIMADMYTLTIREAG
QKTISVPVVHVGNWPDQTAVSSEVTKALASLVDQTAETKRNMYESKGSSA
VADDSKLRPVIHSRAGVGRTAQLIGAMCMNDSRNSQLSVEDMVSQMRVQR
NGIMVQKDEQLDVLIKLAEGQGRPLLNS
Ligand information
Ligand IDSO4
InChIInChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2
InChIKeyQAOWNCQODCNURD-UHFFFAOYSA-L
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0[O-]S(=O)(=O)[O-]
CACTVS 3.341[O-][S]([O-])(=O)=O
ACDLabs 10.04[O-]S([O-])(=O)=O
FormulaO4 S
NameSULFATE ION
ChEMBL
DrugBankDB14546
ZINC
PDB chain1yts Chain A Residue 1 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1yts A ligand-induced conformational change in the Yersinia protein tyrosine phosphatase.
Resolution2.5 Å
Binding residue
(original residue number in PDB)		S403 R404 G406 G408 R409
Binding residue
(residue number reindexed from 1)		S213 R214 G216 G218 R219
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) E290 W354 D356 H402 S403 R409 T410
Catalytic site (residue number reindexed from 1) E100 W164 D166 H212 S213 R219 T220
Enzyme Commision number 3.1.3.48: protein-tyrosine-phosphatase.
Gene Ontology
Molecular Function
GO:0004725 protein tyrosine phosphatase activity
Biological Process
GO:0006470 protein dephosphorylation
GO:0016311 dephosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:1yts, PDBe:1yts, PDBj:1yts
PDBsum1yts
PubMed8528087
UniProtP15273|YOPH_YEREN Tyrosine-protein phosphatase YopH (Gene Name=yopH)

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