Structure of PDB 1ytn Chain A Binding Site BS01

Receptor Information
>1ytn Chain A (length=283) Species: 630 (Yersinia enterocolitica) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VSPYGPEARAELSSRLTTLRNTLAPATNDPRYLQACGGEKLNRFRDIQCR
RQTAVRADLNANYIQVGNTRTIACQYPLQSQLESHFRMLAENRTPVLAVL
ASSSEIANQRFGMPDYFRQSGTYGSITVESKMTQQVGLGDGIMADMYTLT
IREAGQKTISVPVVHVGNWPDQTAVSSEVTKALASLVDQTAETKRNMYES
KGSSAVADDSKLRPVIHCRAGVGRTAQLIGAMCMNDSRNSQLSVEDMVSQ
MRVQRNGIMVQKDEQLDVLIKLAEGQGRPLLNS
Ligand information
Ligand IDNO3
InChIInChI=1S/NO3/c2-1(3)4/q-1
InChIKeyNHNBFGGVMKEFGY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
CACTVS 3.341		[O-][N+]([O-])=O
OpenEye OEToolkits 1.5.0[N+](=O)([O-])[O-]
FormulaN O3
NameNITRATE ION
ChEMBLCHEMBL186200
DrugBankDB14049
ZINC
PDB chain1ytn Chain A Residue 1 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1ytn The X-ray crystal structures of Yersinia tyrosine phosphatase with bound tungstate and nitrate. Mechanistic implications.
Resolution2.4 Å
Binding residue
(original residue number in PDB)		C403 R404 A405 G408 R409
Binding residue
(residue number reindexed from 1)		C218 R219 A220 G223 R224
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) E290 W354 D356 H402 C403 R409 T410
Catalytic site (residue number reindexed from 1) E105 W169 D171 H217 C218 R224 T225
Enzyme Commision number 3.1.3.48: protein-tyrosine-phosphatase.
Gene Ontology
Molecular Function
GO:0004725 protein tyrosine phosphatase activity
Biological Process
GO:0006470 protein dephosphorylation
GO:0016311 dephosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:1ytn, PDBe:1ytn, PDBj:1ytn
PDBsum1ytn
PubMed8702535
UniProtP15273|YOPH_YEREN Tyrosine-protein phosphatase YopH (Gene Name=yopH)

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