Structure of PDB 1ys7 Chain A Binding Site BS01

Receptor Information

>1ys7 Chain A (length=224) Species: 1773 (Mycobacterium tuberculosis)

SPRVLVVDDDSDVLASLERGLRLSGFEVATAVDGAEALRSATENRPDAIV
LDINMPVLDGVSVVTALRAMDNDVPVCVLSARSSVDDRVAGLEAGADDYL
VKPFVLAELVARVKALLRRRGSTATSSSETITVGPLEVDIPGRRARVNGV
DVDLTKREFDLLAVLAEHKTAVLSRAQLLELVWGYDFADTNVVDVFIGYL
RRKLEAGPRLLHTVRGVGFVLRMQ

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 1ys7 Chain A Residue 1002

Receptor-Ligand Complex Structure

Structure summary

• PDB: 1ys7 The structural basis of signal transduction for the response regulator PrrA from Mycobacterium tuberculosis.
• Resolution: 1.58 Å
• Binding residue (original residue number in PDB): D15 D58 N60
• Binding residue (residue number reindexed from 1): D9 D52 N54
• Annotation score: 4

Gene Ontology

Molecular Function

• GO:0000156 phosphorelay response regulator activity
• GO:0000287 magnesium ion binding
• GO:0000976 transcription cis-regulatory region binding
• GO:0003677 DNA binding
• GO:0005509 calcium ion binding
• GO:0046872 metal ion binding

Biological Process

• GO:0000160 phosphorelay signal transduction system
• GO:0006355 regulation of DNA-templated transcription

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0005886 plasma membrane
• GO:0032993 protein-DNA complex

External links

• PDB: RCSB:1ys7, PDBe:1ys7, PDBj:1ys7
• PDBsum: 1ys7
• PubMed: 16434396
• UniProt: P9WGM1|PRRA_MYCTU Transcriptional regulatory protein PrrA (Gene Name=prrA)