Structure of PDB 1yk0 Chain A Binding Site BS01

Receptor Information
>1yk0 Chain A (length=394) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ALPPQKIEVLVLLPQDDSYLFSLTRVRPAIEYALRSVEGLLPPGTRFQVA
YEDSDCGNRALFSLVDRVAAARGAKPDLILGPVCEYAAAPVARLASHWDL
PMLSAGALAAGFQHKDSEYSHLTRVAPAYAKMGEMMLALFRHHHWSRAAL
VYSDDKLERNCYFTLEGVHEVFQEEGLHTSIYSFDETKDLDLEDIVRNIQ
ASERVVIMCASSDTIRSIMLVAHRHGMTSGDYAFFNIELFNSSSYGDGSW
KRGDKHDFEAKQAYSSLQTVTLLRTVKPEFEKFSMEVKSSVEKQGLNMED
YVNMFVEGFHDAILLYVLALHEVLRAGYSKKDGGKIIQQTWNRTFEGIAG
QVSIDANGDRYGDFSVIAMTDVEAGTQEVIGDYFGKEGRFEMRP
Ligand information
>1yk0 Chain E (length=21) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
SCFGGRMDRIGAQSGLGCNSF
Receptor-Ligand Complex Structure
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PDB1yk0 Structural determinants of natriuretic peptide receptor specificity and degeneracy.
Resolution2.4 Å
Binding residue
(original residue number in PDB)		Y93 A96 R100 A116 A117 G118 H121 E125 Y159 K163 R166 Y169 F170 E173 H176 E177 I188
Binding residue
(residue number reindexed from 1)		Y86 A89 R93 A109 A110 G111 H114 E118 Y152 K156 R159 Y162 F163 E166 H169 E170 I181
Enzymatic activity
Enzyme Commision number ?
Gene Ontology

View graph for
Cellular Component
External links
PDB RCSB:1yk0, PDBe:1yk0, PDBj:1yk0
PDBsum1yk0
PubMed16870210
UniProtP17342|ANPRC_HUMAN Atrial natriuretic peptide receptor 3 (Gene Name=NPR3)

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