Structure of PDB 1yii Chain A Binding Site BS01

Receptor Information
>1yii Chain A (length=316) Species: 9031 (Gallus gallus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AKYTRGTVTAFSPFDARADAEALRKAMKGMGTDEETILKILTSRNNAQRQ
EIASAFKTLFGRDLVDDLKSELTGKFETLMVSLMRPARIFDAHALKHAIK
GAGTNEKVLTEILASRTPAEVQNIKQVYMQEYEANLEDKITGETSGHFQR
LLVVLLQANRDPDGRVDEALVEKDAQVLFRAGELKWGTDEETFITILGTR
SVSHLRRVFDKYMTISGFQIEETIDRETSGDLEKLLLAVVKCIRSVPAYF
AETLYYSMKGAGTDDDTLIRVMVSRSEIDLLDIRHEFRKNFAKSLYQMIQ
KDTSGDYRKALLLLCG
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain1yii Chain A Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1yii Crystal Structures of Chicken Annexin A5 in Complex with Functional Modifiers Ca2+ and Zn2+ Reveal Zn2+ Induced Formation of Non-Planar Assemblies
Resolution1.42 Å
Binding residue
(original residue number in PDB)		M28 G30 G32 E72
Binding residue
(residue number reindexed from 1)		M27 G29 G31 E71
Annotation score5
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0001786 phosphatidylserine binding
GO:0005262 calcium channel activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0005544 calcium-dependent phospholipid binding
Biological Process
GO:0050819 negative regulation of coagulation
GO:0055074 calcium ion homeostasis
GO:0070588 calcium ion transmembrane transport
Cellular Component
GO:0005737 cytoplasm
GO:0012506 vesicle membrane
GO:0031982 vesicle
GO:0034704 calcium channel complex
GO:0042383 sarcolemma

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1yii, PDBe:1yii, PDBj:1yii
PDBsum1yii
PubMed
UniProtP17153|ANXA5_CHICK Annexin A5 (Gene Name=ANXA5)

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