Structure of PDB 1ygr Chain A Binding Site BS01

Receptor Information
>1ygr Chain A (length=574) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EKQLMNVEPIHADILLETYKRKIADEGRPFLAEFQSIPRVFSKFPIKEAR
KPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYI
AAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGT
RAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKATGREVTHIQFTSWPDHG
VPEDPHLLLKLRRRVNAFSNFFSGPIVVHSSAGVGRTGTYIGIDAMLEGL
EAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLS
ELHPYLHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQHIGNQEENKSKNR
NSNVIPYDYNRVPLKSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQM
IFQRKVKVIVMLTELKHGDQEICAQYWGEGKQTYGDIEVDLKDTDKSSTY
TLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLP
QKNHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRK
ARLGMVSTFEQYQFLYDVIASTYP
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB1ygr Structural basis for the function and regulation of the receptor protein tyrosine phosphatase CD45.
Resolution2.9 Å
Binding residue
(original residue number in PDB)		Y658 V659 D660 R734 H797 S828 S829 A830 V832 G833 R834 L869 Q872
Binding residue
(residue number reindexed from 1)		Y60 V61 D62 R136 H199 S230 S231 A232 V234 G235 R236 L271 Q274
Enzymatic activity
Catalytic site (original residue number in PDB) D796 S828 R834 T835 Q872
Catalytic site (residue number reindexed from 1) D198 S230 R236 T237 Q274
Enzyme Commision number 3.1.3.48: protein-tyrosine-phosphatase.
Gene Ontology
Molecular Function
GO:0004725 protein tyrosine phosphatase activity
Biological Process
GO:0006470 protein dephosphorylation
GO:0016311 dephosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:1ygr, PDBe:1ygr, PDBj:1ygr
PDBsum1ygr
PubMed15684325
UniProtP08575|PTPRC_HUMAN Receptor-type tyrosine-protein phosphatase C (Gene Name=PTPRC)

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