Structure of PDB 1yf8 Chain A Binding Site BS01

Receptor Information
>1yf8 Chain A (length=240) Species: 3972 (Viscum album) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
YERLDLDVTSQTTGEEYFRFITLLRDYVSSGSFSNEIPLLRQSGGGVEAA
RFVLVELTNEGGDSITAAIDVTNLYVVAYQAGSQSYFLSGPGTHLFTGTT
RSSLPFNGSYPDLEQYAGHRKQIPLGIDQLIQSVTALRFPGNTRTQARSI
LILIQMISEAARFNPILWRARQYINSGASFLPDVYMLELETSWGQQSTQV
QQSTEGVFNNPIRLAIPGNFVTLTNVRDVIASLAIMLFVC
Ligand information
Ligand IDP6C
InChIInChI=1S/C10H11N5O2/c1-4(2)6-7-8(15-10(11)14-6)12-3-5(13-7)9(16)17/h3-4H,1-2H3,(H,16,17)(H2,11,12,14,15)
InChIKeyGPHPGFBRJYCUDO-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04O=C(O)c1nc2c(nc1)nc(nc2C(C)C)N
CACTVS 3.341CC(C)c1nc(N)nc2ncc(nc12)C(O)=O
OpenEye OEToolkits 1.5.0CC(C)c1c2c(ncc(n2)C(=O)O)nc(n1)N
FormulaC10 H11 N5 O2
Name2-AMINO-4-ISOPROPYL-PTERIDINE-6-CARBOXYLIC ACID
ChEMBL
DrugBank
ZINCZINC000005963371
PDB chain1yf8 Chain A Residue 1001 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB1yf8 Crystal structure of himalayan mistletoe ribosome-inactivating protein reveals the presence of a natural inhibitor and a new functionally active sugar-binding site.
Resolution2.8 Å
Binding residue
(original residue number in PDB)		Y75 S109 Y110 R162 W193
Binding residue
(residue number reindexed from 1)		Y75 S109 Y110 R162 W193
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) V76 E159 R162
Catalytic site (residue number reindexed from 1) V76 E159 R162
Enzyme Commision number 3.2.2.22: rRNA N-glycosylase.
Gene Ontology
Molecular Function
GO:0030598 rRNA N-glycosylase activity
Biological Process
GO:0017148 negative regulation of translation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:1yf8, PDBe:1yf8, PDBj:1yf8
PDBsum1yf8
PubMed15774467
UniProtQ6ITZ3|ML4_VISAL Beta-galactoside-specific lectin 4

[Back to BioLiP]