Structure of PDB 1yf4 Chain A Binding Site BS01

Receptor Information
>1yf4 Chain A (length=223) Species: 9823 (Sus scrofa) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IVGGYTCAANSIPYQVSLNSGSHFCGGSLINSQWVVSAAHCYKSRIQVRL
GEHNIDVLEGNEQFINAAKIITHPNFNGNTLDNDIMLIKLSSPATLNSRV
ATVSLPRSCAAAGTECLISGWGNTKSSGSSYPSLLQCLKAPVLSDSSCKS
SYPGQITGNMICVGFLEGGKDSCQGDSGGPVVCNGQLQGIVSWGYGCAQK
NKPGVYTKVCNYVNWIQQTIAAN
Ligand information
Receptor-Ligand Complex Structure
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PDB1yf4 Trypsin inhibition by a Peptide hormone: crystal structure of trypsin-vasopressin complex
Resolution1.98 Å
Binding residue
(original residue number in PDB)		H57 S146 G148 Q175 D189 S190 C191 Q192 G193 S195 S214 W215 G216 Y217 G219
Binding residue
(residue number reindexed from 1)		H40 S126 G128 Q155 D171 S172 C173 Q174 G175 S177 S192 W193 G194 Y195 G196
Enzymatic activity
Catalytic site (original residue number in PDB) H57 D102 Q192 G193 D194 S195 G196
Catalytic site (residue number reindexed from 1) H40 D84 Q174 G175 D176 S177 G178
Enzyme Commision number 3.4.21.4: trypsin.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0008236 serine-type peptidase activity
GO:0046872 metal ion binding
Biological Process
GO:0006508 proteolysis
GO:0007586 digestion
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space

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Biological Process
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Cellular Component
External links
PDB RCSB:1yf4, PDBe:1yf4, PDBj:1yf4
PDBsum1yf4
PubMed15854654
UniProtP00761|TRYP_PIG Trypsin

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