Structure of PDB 1y98 Chain A Binding Site BS01

Receptor Information
>1y98 Chain A (length=211) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RMSMVVSGLTPEEFMLVYKFARKHHITLTNLITEETTHVVMKTDAEFVCE
RTLKYFLGIAGGKWVVSYFWVTQSIKERKMLNEHDFEVRGDVVNGRNHQG
PKRARESQDRKIFRGLEICCYGPFTNMPTDQLEWMVQLCGASVVKELSSF
TLGTGVHPIVVVQPDAWTEDNGFHAIGQMCEAPVVTREWVLDSVALYQCQ
ELDTYLIPQIP
Ligand information
Receptor-Ligand Complex Structure
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PDB1y98 Structural Basis for Cell Cycle Checkpoint Control by the BRCA1-CtIP Complex.
Resolution2.5 Å
Binding residue
(original residue number in PDB)		S1655 G1656 L1657 R1699 K1702 V1741 N1774 M1775
Binding residue
(residue number reindexed from 1)		S7 G8 L9 R51 K54 V93 N126 M127
Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004842 ubiquitin-protein transferase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006281 DNA repair
GO:0006974 DNA damage response
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1y98, PDBe:1y98, PDBj:1y98
PDBsum1y98
PubMed16101277
UniProtP38398|BRCA1_HUMAN Breast cancer type 1 susceptibility protein (Gene Name=BRCA1)

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