Structure of PDB 1y7l Chain A Binding Site BS01

Receptor Information

>1y7l Chain A (length=310) Species: 727 (Haemophilus influenzae)

AIYADNSYSIGNTPLVRLKHFGHNGNVVVKIEGRNPSYSVKCRIGANMVW
QAEKDGTLTKGKEIVDATSGNTGIALAYVAAARGYKITLTMPETMSLERK
RLLCGLGVNLVLTEGAKGMKGAIAKAEEIVASDPSRYVMLKQFENPANPQ
IHRETTGPEIWKDTDGKVDVVVAGVGTGGSITGISRAIKLDFGKQITSVA
VEPVESPVISQTLAGEEVKPGPHKIQGIGAGFIPKNLDLSIIDRVETVDS
DTALATARRLMAEEGILAGISSGAAVAAADRLAKLPEFADKLIVVILPSA
SERYLSTALF

Ligand information

>1y7l Chain P (length=4) Species: 71421 (Haemophilus influenzae Rd KW20)

NLNI

Receptor-Ligand Complex Structure

Structure summary

• PDB: 1y7l The active site of O-acetylserine sulfhydrylase is the anchor point for bienzyme complex formation with serine acetyltransferase.
• Resolution: 1.55 Å
• Binding residue (original residue number in PDB): X42 T69 S70 T73 M120 Q143
• Binding residue (residue number reindexed from 1): X41 T68 S69 T72 M119 Q142

Enzymatic activity

• Catalytic site (original residue number in PDB): K42 S272 P299
• Catalytic site (residue number reindexed from 1): K41 S271 P298
• Enzyme Commision number: 2.5.1.47: cysteine synthase.

Gene Ontology

Molecular Function

• GO:0004124 cysteine synthase activity
• GO:0016740 transferase activity
• GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups
• GO:0080146 L-cysteine desulfhydrase activity

Biological Process

• GO:0006535 cysteine biosynthetic process from serine
• GO:0019344 cysteine biosynthetic process

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:1y7l, PDBe:1y7l, PDBj:1y7l
• PDBsum: 1y7l
• PubMed: 15838047
• UniProt: P45040|CYSK_HAEIN Cysteine synthase (Gene Name=cysK)