Structure of PDB 1y44 Chain A Binding Site BS01

Receptor Information

>1y44 Chain A (length=269) Species: 1423 (Bacillus subtilis) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

MELLFLGTGAGIPAKARNVTSVALKLLEERRSVWLFDCGEATQHQMLHTT
IKPRKIEKIFITHMHGDHVYGLPGLLGSRSFQGGEDELTVYGPKGIKAFI
ETSLAVTKTHLTYPLAIQEIEEGIVFEDDQFIVTAVSVIHGVEAFGYRVQ
EKDVPGSLLEPPKKGRSVVFSGDTRVSDKLKELARDCDVMVHEATFAKED
RKLAYDYYHSTTEQAAVTAKEARAKQLILTHISARYQGDASLELQKEAVD
VFPNSVAAYDFLEVNVPRG

Ligand information

Ligand ID

InChI

InChI=1S/Zn/q+2

InChIKey

PTFCDOFLOPIGGS-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Zn++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Zn+2]

Formula

Name

ZINC ION

PDB chain

1y44 Chain A Residue 400 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	1y44 Structural basis for substrate binding, cleavage and allostery in the tRNA maturase RNase Z.
Resolution	2.1 Å
Binding residue (original residue number in PDB)	H63 H65 H140 D211
Binding residue (residue number reindexed from 1)	H63 H65 H140 D173
Annotation score	4

Enzymatic activity

Enzyme Commision number

3.1.26.11: ribonuclease Z.

Gene Ontology

	Molecular Function
GO:0004519	endonuclease activity
GO:0008270	zinc ion binding
GO:0016891	RNA endonuclease activity, producing 5'-phosphomonoesters
GO:0042781	3'-tRNA processing endoribonuclease activity
GO:0042802	identical protein binding
GO:0046872	metal ion binding

	Biological Process
GO:0008033	tRNA processing
GO:0042780	tRNA 3'-end processing

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Molecular Function

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Biological Process

External links

PDB	RCSB:1y44, PDBe:1y44, PDBj:1y44
PDBsum	1y44
PubMed	15654328
UniProt	P54548\|RNZ_BACSU Ribonuclease Z (Gene Name=rnz)

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