Structure of PDB 1xz1 Chain A Binding Site BS01

Receptor Information
>1xz1 Chain A (length=168) Species: 9796 (Equus caballus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SQIRQNYSTEVEAAVNRLVNLYLRASYTYLSLGFYFDRDDVALEGVCHFF
RELAEEKREGAERLLKMQNQRGGRALFQDLQKPSQDEWGTTLDAMKAAIV
LEKSLNQALLDLHALGSAQADPHLCDFLESHFLDEEVKLIKKMGDHLTNI
QRLVQAGLGEYLFERLTL
Ligand information
Ligand IDHLT
InChIInChI=1S/C2HBrClF3/c3-1(4)2(5,6)7/h1H/t1-/m0/s1
InChIKeyBCQZXOMGPXTTIC-SFOWXEAESA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0[C@@H](C(F)(F)F)(Cl)Br
OpenEye OEToolkits 1.5.0C(C(F)(F)F)(Cl)Br
ACDLabs 10.04BrC(Cl)C(F)(F)F
CACTVS 3.341FC(F)(F)[C@H](Cl)Br
CACTVS 3.341FC(F)(F)[CH](Cl)Br
FormulaC2 H Br Cl F3
Name2-BROMO-2-CHLORO-1,1,1-TRIFLUOROETHANE
ChEMBL
DrugBank
ZINCZINC000008220828
PDB chain1xz1 Chain A Residue 2001 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1xz1 Structural basis for high-affinity volatile anesthetic binding in a natural 4-helix bundle protein.
Resolution1.75 Å
Binding residue
(original residue number in PDB)		L24 Y28
Binding residue
(residue number reindexed from 1)		L23 Y27
Annotation score1
Binding affinityMOAD: Ka~100000M^-1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005506 iron ion binding
GO:0008198 ferrous iron binding
GO:0008199 ferric iron binding
GO:0046872 metal ion binding
Biological Process
GO:0006826 iron ion transport
GO:0006879 intracellular iron ion homeostasis
GO:0006880 intracellular sequestering of iron ion
Cellular Component
GO:0005737 cytoplasm
GO:0005764 lysosome
GO:0005776 autophagosome
GO:0031410 cytoplasmic vesicle
GO:0044754 autolysosome
GO:0070288 ferritin complex

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Biological Process
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Cellular Component
External links
PDB RCSB:1xz1, PDBe:1xz1, PDBj:1xz1
PDBsum1xz1
PubMed15791007
UniProtP02791|FRIL_HORSE Ferritin light chain (Gene Name=FTL)

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