Structure of PDB 1xvp Chain A Binding Site BS01

Receptor Information
>1xvp Chain A (length=232) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NEDMPVERILEAELAVEPKTETYVEANMGLNPSSPNDPVTNICQAADKQL
FTLVEWAKRIPHFSELPLDDQVILLRAGWNELLIASFSHRSIAVKDGILL
ATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDMQMDKTELGCLRAIVLF
NPDSKGLSNPAEVEALREKVYASLEAYCKHKYPEQPGRFAKLLLRLPALR
SIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAP
Ligand information
Receptor-Ligand Complex Structure
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PDB1xvp A Structural Basis for Constitutive Activity in the Human CAR/RXRalpha Heterodimer.
Resolution2.6 Å
Binding residue
(original residue number in PDB)		V280 K284 V298 L301 T449 F450 E453
Binding residue
(residue number reindexed from 1)		V54 K58 V72 L75 T223 F224 E227
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003707 nuclear steroid receptor activity
GO:0008270 zinc ion binding
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1xvp, PDBe:1xvp, PDBj:1xvp
PDBsum1xvp
PubMed15610735
UniProtP19793|RXRA_HUMAN Retinoic acid receptor RXR-alpha (Gene Name=RXRA)

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