Structure of PDB 1xs5 Chain A Binding Site BS01

Receptor Information
>1xs5 Chain A (length=240) Species: 160 (Treponema pallidum) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KDETVGVGVLSEPHARLLEIAKEEVKKQHIELRIVEFTNYVALNEAVMRG
DILMNFFQHVPHMQQFNQEHNGDLVSVGNVHVEPLALYSRTYRHVSDFPA
GAVIAIPNDSSNEARALRLLEAAGFIRMRAGSGLFATVEDVQQNVRNVVL
QEVESALLPRVFDQVDGAVINGNYAIMAGLSARRDGLAVEPDASAYANVL
VVKRGNEADARVQAVLRALCGGRVRTYLKERYKGGEVAPA
Ligand information
Ligand IDMET
InChIInChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1
InChIKeyFFEARJCKVFRZRR-BYPYZUCNSA-N
SMILES
SoftwareSMILES
CACTVS 3.341CSCC[CH](N)C(O)=O
OpenEye OEToolkits 1.5.0CSCCC(C(=O)O)N
CACTVS 3.341CSCC[C@H](N)C(O)=O
OpenEye OEToolkits 1.5.0CSCC[C@@H](C(=O)O)N
ACDLabs 10.04O=C(O)C(N)CCSC
FormulaC5 H11 N O2 S
NameMETHIONINE
ChEMBLCHEMBL42336
DrugBankDB00134
ZINCZINC000001532529
PDB chain1xs5 Chain A Residue 301 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB1xs5 Structural evidence that the 32-kilodalton lipoprotein (Tp32) of Treponema pallidum is an L-methionine-binding protein
Resolution1.85 Å
Binding residue
(original residue number in PDB)		Y44 F61 Q62 H63 H66 E87 N116 R119 N175 N202
Binding residue
(residue number reindexed from 1)		Y40 F57 Q58 H59 H62 E83 N112 R115 N171 N198
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Cellular Component
GO:0005886 plasma membrane

View graph for
Cellular Component
External links
PDB RCSB:1xs5, PDBe:1xs5, PDBj:1xs5
PDBsum1xs5
PubMed15489229
UniProtO07950|TPN32_TREPA Membrane lipoprotein TpN32 (Gene Name=tpn32)

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