Structure of PDB 1xm1 Chain A Binding Site BS01

Receptor Information
>1xm1 Chain A (length=284) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ADCGLRPLFEKKSLEDKTERELLESYIIVEGSDAEIGMSPWQVMLFRKSP
QELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDLLVRIGKHSRTRYER
NIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDR
ETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQVVNLPIVERPVC
KDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMG
IVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQF
Ligand information
Receptor-Ligand Complex Structure
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PDB1xm1 Nonbasic Thrombin Inhibitor Complex
Resolution2.3 Å
Binding residue
(original residue number in PDB)		Q38 L65 R73 T74 R75 Y76 K81 I82 M84 Q151
Binding residue
(residue number reindexed from 1)		Q51 L87 R95 T96 R97 Y98 K104 I105 M107 Q183
Enzymatic activity
Catalytic site (original residue number in PDB) H57 D102 E192 G193 D194 S195 G196
Catalytic site (residue number reindexed from 1) H70 D126 E229 G230 D231 S232 G233
Enzyme Commision number 3.4.21.5: thrombin.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation
Cellular Component
GO:0005576 extracellular region

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Cellular Component
External links
PDB RCSB:1xm1, PDBe:1xm1, PDBj:1xm1
PDBsum1xm1
PubMed
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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