Structure of PDB 1xhm Chain A Binding Site BS01

Receptor Information

>1xhm Chain A (length=339) Species: 9913 (Bos taurus)

SELDQLRQEAEQLKNQIRDARKACADATLSQITNNIDPVGRIQMRTRRTL
RGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVM
TCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRF
LDDNQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVS
GACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCR
LFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALK
ADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN

Ligand information

>1xhm Chain C (length=13)

SIGKAFKILGYPD

Receptor-Ligand Complex Structure

Structure summary

• PDB: 1xhm Structural and Molecular Characterization of a Preferred Protein Interaction Surface on G Protein betagamma Subunits.
• Resolution: 2.7 Å
• Binding residue (original residue number in PDB): Y59 W99 M101 L117 Y145 D186 M188 D228 N230 W332
• Binding residue (residue number reindexed from 1): Y58 W98 M100 L116 Y144 D185 M187 D227 N229 W331

Gene Ontology

Molecular Function

• GO:0005515 protein binding
• GO:0030159 signaling receptor complex adaptor activity

Biological Process

• GO:0007165 signal transduction
• GO:0007186 G protein-coupled receptor signaling pathway
• GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway
• GO:0071380 cellular response to prostaglandin E stimulus
• GO:0071870 cellular response to catecholamine stimulus

Cellular Component

• GO:0005737 cytoplasm
• GO:0005834 heterotrimeric G-protein complex
• GO:0016020 membrane
• GO:0097381 photoreceptor disc membrane

External links

• PDB: RCSB:1xhm, PDBe:1xhm, PDBj:1xhm
• PDBsum: 1xhm
• PubMed: 16060668
• UniProt: P62871|GBB1_BOVIN Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 (Gene Name=GNB1)