Structure of PDB 1x9n Chain A Binding Site BS01

Receptor Information
>1x9n Chain A (length=632) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DPSGYNPAKNNYHPVEDACWKPGQKVPYLAVARTFEKIEEVSARLRMVET
LSNLLRSVVALSPPDLLPVLYLSLNHLGPPQQGLELGVGDGVLLKAVAQA
TGRQLESVRAEAAEKGDVGLVAEMLPPPPLTASGVFSKFRDIARLTGSAS
TAKKIDIIKGLFVACRHSEARFIARSLSGRLRLGLAEQSVLAALSQAVSL
TPPGQEFPPAMVDAGKGKTAEARKTWLEEQGMILKQTFCEVPDLDRIIPV
LLEHGLERLPEHCKLSPGIPLKPMLAHPTRGISEVLKRFEEAAFTCEYKY
DGQRAQIHALEGGEVKIFSRNQEDNTGKYPDIISRIPKIKLPSVTSFILD
TEAVAWDREKKQIQPFQVLTTRKRKEVDASEIQVQVCLYAFDLIYLNGES
LVREPLSRRRQLLRENFVETEGEFVFATSLDTKDIEQIAEFLEQSVKDSC
EGLMVKTLDVDATYEIAKRSHNWLKLKKDYLDGVGDTLDLVVIGAYLGRG
KRAGRYGGFLLASYDEDSEELQAICKLGTGFSDEELEEHHQSLKALVLPS
PRPYVRIDGAVIPDHWLDPSAVWEVKCADLSLSPIYPAARGLVDSDKGIS
LRFPRFIRVREDKQPEQATTSAQVACLYRKQS
Ligand information
Receptor-Ligand Complex Structure
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PDB1x9n Human DNA ligase I completely encircles and partially unwinds nicked DNA.
Resolution3.0 Å
Binding residue
(original residue number in PDB)		E346 G348 G350 Q572 S588 E592 N594 F635 F872
Binding residue
(residue number reindexed from 1)		E85 G87 G89 Q303 S319 E323 N325 F366 F603
Enzymatic activity
Enzyme Commision number 6.5.1.1: DNA ligase (ATP).
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003909 DNA ligase activity
GO:0003910 DNA ligase (ATP) activity
GO:0005524 ATP binding
Biological Process
GO:0006281 DNA repair
GO:0006310 DNA recombination
GO:0071897 DNA biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:1x9n, PDBe:1x9n, PDBj:1x9n
PDBsum1x9n
PubMed15565146
UniProtP18858|DNLI1_HUMAN DNA ligase 1 (Gene Name=LIG1)

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