Structure of PDB 1x9m Chain A Binding Site BS01

Receptor Information
>1x9m Chain A (length=675) Species: 10760 (Escherichia phage T7) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MIVSDIEANALLESVTKFHCGVIYDYSTAEYVSYRPSDFGAYLDALEAEV
ARGGLIVFHNGHKYDVPALTKLAKLQLNREFHLPRENCIDTLVLSRLIHS
NLKDTDMGLLRSGKLPGALEAWGYRLGEMKGEYKDDFKRMLEEQGEEYVD
GMEWWNFNEEMMDYNVQDVVVTKALLEKLLSDKHYFPPEIDFTDVGYTTF
WSESLEAVDIEHRAAWLLAKQERNGFPFDTKAIEELYVELAARRSELLRK
LTETFGSWYQPKGGTEMFCHPRTGKPLPKYPRIKTPKVGGIFKCELDTRE
YVAGAPYTPVEHVVFNPSSRDHIQKKLQEAGWVPTKYTDKGAPVVDDEVL
EGVRVDDPEKQAAIDLIKEYLMIQKRIGQSAEGDKAWLRYVAEDGKIHGS
VNPNGAVTGRATHAFPNLAQIPGVRSPYGEQCRAAFGAEHHLDGITGKPW
VQAGIDASGLELRCLAHFMARFDNGEYAHEILNGDIHTKNQIAAELPTRD
NAKTFIYGFLYGAGDEKIGQIVGAGKERGKELKKKFLENTPAIAALRESI
QQTLVEVKWKRRWIKGLDGRKVHVRSPHAALNTLLQSAGALICKLWIIKT
EEMLVEKGLKHGWDGDFAYMAWVHDEIQVGCRTEEIAQVVIETAQEAMRW
VGDHWNFRCLLDTEGKMGPNWAICH
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB1x9m Crystal structures of 2-acetylaminofluorene and 2-aminofluorene in complex with T7 DNA polymerase reveal mechanisms of mutagenesis.
Resolution2.1 Å
Binding residue
(original residue number in PDB)		R111 T357 K359 V363 V364 D365 D366 K394 R395 R429 A438 Q439 I440 G442 H653
Binding residue
(residue number reindexed from 1)		R111 T338 K340 V344 V345 D346 D347 K375 R376 R410 A419 Q420 I421 G423 H624
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
3.1.11.-
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0004527 exonuclease activity
GO:0004529 DNA exonuclease activity
GO:0005515 protein binding
GO:0008408 3'-5' exonuclease activity
GO:0046872 metal ion binding
Biological Process
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication
GO:0006302 double-strand break repair
GO:0039693 viral DNA genome replication
GO:0090592 DNA synthesis involved in DNA replication

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Molecular Function
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Biological Process
External links
PDB RCSB:1x9m, PDBe:1x9m, PDBj:1x9m
PDBsum1x9m
PubMed15528277
UniProtP00581|DPOL_BPT7 DNA-directed DNA polymerase (Gene Name=5)

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