Structure of PDB 1x7p Chain A Binding Site BS01

Receptor Information
>1x7p Chain A (length=265) Species: 1938 (Streptomyces viridochromogenes) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RNARFQQWQALLGNRNKRTRAGEFLVMGVRPISLAVEHGWPVRTLLYDGQ
RELSKWARELLRTVRTEQIAMAPDLLMELGEKNEAPPEVVAVVEMPADDL
DRIPVREDFLGVLFDRPTSPGNIGSIIRSADALGAHGLIVAGHAADVYDP
KSVRSSTGSLFSLPAVRVPSPGEVMDWVEARRAAGTPIVLVGTDEHGDCD
VFDFDFTQPTLLLIGNETAGLSNAWRTLCDYTVSIPMAGSASSLNAANAA
TAILYEAVRQRISGR
Ligand information
Ligand IDSAM
InChIInChI=1S/C15H22N6O5S/c1-27(3-2-7(16)15(24)25)4-8-10(22)11(23)14(26-8)21-6-20-9-12(17)18-5-19-13(9)21/h5-8,10-11,14,22-23H,2-4,16H2,1H3,(H2-,17,18,19,24,25)/t7-,8+,10+,11+,14+,27-/m0/s1
InChIKeyMEFKEPWMEQBLKI-FCKMPRQPSA-N
SMILES
SoftwareSMILES
CACTVS 3.341C[S@@+](CC[C@H](N)C([O-])=O)C[C@H]1O[C@H]([C@H](O)[C@@H]1O)n2cnc3c(N)ncnc23
OpenEye OEToolkits 1.5.0C[S+](CCC(C(=O)[O-])N)CC1C(C(C(O1)n2cnc3c2ncnc3N)O)O
CACTVS 3.341C[S+](CC[CH](N)C([O-])=O)C[CH]1O[CH]([CH](O)[CH]1O)n2cnc3c(N)ncnc23
OpenEye OEToolkits 1.5.0C[S@@+](CC[C@@H](C(=O)[O-])N)C[C@@H]1[C@H]([C@H]([C@@H](O1)n2cnc3c2ncnc3N)O)O
ACDLabs 10.04[O-]C(=O)C(N)CC[S+](C)CC3OC(n2cnc1c(ncnc12)N)C(O)C3O
FormulaC15 H22 N6 O5 S
NameS-ADENOSYLMETHIONINE
ChEMBLCHEMBL1235831
DrugBank
ZINC
PDB chain1x7p Chain A Residue 301 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1x7p Structure and function of the antibiotic resistance-mediating methyltransferase AviRb from Streptomyces viridochromogenes
Resolution2.55 Å
Binding residue
(original residue number in PDB)		T210 D211 E212 G232 E234 G237 S251 I252 M254 L261 A263 A266
Binding residue
(residue number reindexed from 1)		T193 D194 E195 G215 E217 G220 S234 I235 M237 L244 A246 A249
Annotation score5
Enzymatic activity
Enzyme Commision number 2.1.1.208: 23S rRNA (uridine(2479)-2'-O)-methyltransferase.
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0008168 methyltransferase activity
GO:0008173 RNA methyltransferase activity
GO:0008650 rRNA (uridine-2'-O-)-methyltransferase activity
Biological Process
GO:0006396 RNA processing
GO:0031167 rRNA methylation
GO:0032259 methylation
GO:0046677 response to antibiotic

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:1x7p, PDBe:1x7p, PDBj:1x7p
PDBsum1x7p
PubMed15581897
UniProtQ9F5K6|AVRB_STRVR 23S rRNA (uridine(2479)-2'-O)-methyltransferase (Gene Name=aviRb)

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