Structure of PDB 1x7n Chain A Binding Site BS01

Receptor Information

>1x7n Chain A (length=189) Species: 2261 (Pyrococcus furiosus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

MMYKEPFGVKVDFETGIIEGAKKSVRRLSDMEGYFVDERAWKELVEKEDP
VVYEVYAVEQEEKEGDLNFATTVLYPGKVGKEFFFTKGHFHAKLDRAEVY
VALKGKGGMLLQTPEGDAKWISMEPGTVVYVPPYWAHRTVNIGDEPFIFL
AIYPADAGHDYGTIAEKGFSKIVIEENGEVKVVDNPRWK

Ligand information

Ligand ID

InChI

InChI=1S/Mn/q+2

InChIKey

WAEMQWOKJMHJLA-UHFFFAOYSA-N

SMILES

Software	SMILES
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Mn+2]
CACTVS 3.341	[Mn++]

Formula

Name

MANGANESE (II) ION

PDB chain

1x7n Chain A Residue 400 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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PDB	1x7n The structures of inhibitor complexes of Pyrococcus furiosus phosphoglucose isomerase provide insights into substrate binding and catalysis.
Resolution	1.89 Å
Binding residue (original residue number in PDB)	H88 H90 E97 H136
Binding residue (residue number reindexed from 1)	H89 H91 E98 H137
Annotation score	1

Enzymatic activity

Enzyme Commision number

5.3.1.9: glucose-6-phosphate isomerase.

Gene Ontology

	Molecular Function
GO:0004347	glucose-6-phosphate isomerase activity
GO:0005506	iron ion binding
GO:0016853	isomerase activity
GO:0046872	metal ion binding

	Biological Process
GO:0006094	gluconeogenesis
GO:0006096	glycolytic process

	Cellular Component
GO:0005737	cytoplasm

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Cellular Component

External links

PDB	RCSB:1x7n, PDBe:1x7n, PDBj:1x7n
PDBsum	1x7n
PubMed	15465052
UniProt	P83194\|G6PI_PYRFU Glucose-6-phosphate isomerase (Gene Name=pgiA)

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