Structure of PDB 1x78 Chain A Binding Site BS01

Receptor Information

>1x78 Chain A (length=228) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

LSPEQLVLTLLEAEPPHVLISRPSAPFTEASMMMSLTKLADKELVHMISW
AKKIPGFVELSLFDQVRLLESCWMEVLMMGLMWRSIDHPGKLIFAPDLVL
DRDEGKCVEGILEIFDMLLATTSRFRELKLQHKEYLCVKAMILLNSSMDS
SRKLAHLLNAVTDALVWVIAKSGISSQQQSMRLANLLMLLSHVRHASNKG
MEHLLNMKCKNVVPVYDLLLEMLNAHVL

Ligand information

>1x78 Chain C (length=9) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

KLVQLLTTT

Receptor-Ligand Complex Structure

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Structure summary

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PDB	1x78 Structure-Based Design of Estrogen Receptor-Beta Selective Ligands
Resolution	2.3 Å
Binding residue (original residue number in PDB)	I310 K314 D489 L490 E493
Binding residue (residue number reindexed from 1)	I48 K52 D217 L218 E221

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0003677	DNA binding
GO:0004879	nuclear receptor activity

	Biological Process
GO:0006355	regulation of DNA-templated transcription

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Molecular Function

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Biological Process

External links

PDB	RCSB:1x78, PDBe:1x78, PDBj:1x78
PDBsum	1x78
PubMed	15548008
UniProt	Q92731\|ESR2_HUMAN Estrogen receptor beta (Gene Name=ESR2)

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