Structure of PDB 1x2r Chain A Binding Site BS01
Receptor Information
>1x2r Chain A (length=290) Species:
10090
(Mus musculus) [
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VGRLIYTAGGYFRQSLSYLEAYNPSNGSWLRLADLQVPRSGLAGCVVGGL
LYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCASMSVPRNRIGVGVIDG
HIYAVGGSHGCIHHSSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLY
AVGGFDGTNRLNSAECYYPERNEWRMITPMNTIRSGAGVCVLHNCIYAAG
GYDGQDQLNSVERYDVETETWTFVAPMRHHRSALGITVHQGKIYVLGGYD
GHTFLDSVECYDPDSDTWSEVTRMTSGRSGVGVAVTMEPC
Ligand information
>1x2r Chain B (length=9) Species:
10090
(Mus musculus) [
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LDEETGEFL
Receptor-Ligand Complex Structure
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PDB
1x2r
Structural basis for defects of keap1 activity provoked by its point mutations in lung cancer
Resolution
1.7 Å
Binding residue
(original residue number in PDB)
Y334 S363 N382 N387 R415 R483 S508 Y525 Q530 S555 Y572 F577 S602
Binding residue
(residue number reindexed from 1)
Y11 S40 N59 N64 R92 R160 S185 Y202 Q207 S232 Y249 F254 S279
Enzymatic activity
Enzyme Commision number
?
External links
PDB
RCSB:1x2r
,
PDBe:1x2r
,
PDBj:1x2r
PDBsum
1x2r
PubMed
16507366
UniProt
Q9Z2X8
|KEAP1_MOUSE Kelch-like ECH-associated protein 1 (Gene Name=Keap1)
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