Structure of PDB 1x1c Chain A Binding Site BS01

Receptor Information

>1x1c Chain A (length=337) Species: 194439 (Chlorobaculum tepidum TLS)

SNNDLLNYYHRANELVFKGLIEFSCMKAAIELDLFSHMAEGPKDLATLAA
DTGSVPPRLEMLLETLRQMRVINLEDGKWSLTEFADYMFSPTPKEPNLHQ
TPVAKAMAFLADDFYMGLSQAVRGQKNFKGQVPYPPVTREDNLYFEEIHR
SNAKFAIQLLLEEAKLDGVKKMIDVGGGIGDISAAMLKHFPELDSTILNL
PGAIDLVNENAAEKGVADRMRGIAVDIYKESYPEADAVLFCRILYSANEQ
LSTIMCKKAFDAMRSGGRLLILDMVIDDPENPNFDYLSHYILGAGMPFSV
LGFKEQARYKEILESLGYKDVTMVRKYDHLLVQAVKP

Ligand information

• Ligand ID: ZN
• InChI: InChI=1S/Zn/q+2
• InChIKey: PTFCDOFLOPIGGS-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Zn++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Zn+2]
• Formula: Zn
• Name: ZINC ION
• ChEMBL: CHEMBL1236970
• DrugBank: DB14532
• PDB chain: 1x1c Chain A Residue 5002

Receptor-Ligand Complex Structure

Structure summary

• PDB: 1x1c Crystal Structures of BchU, a Methyltransferase Involved in Bacteriochlorophyll c Biosynthesis, and its Complex with S-adenosylhomocysteine: Implications for Reaction Mechanism.
• Resolution: 2.85 Å
• Binding residue (original residue number in PDB): D286 H290
• Binding residue (residue number reindexed from 1): D285 H289
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 2.1.1.333: bacteriochlorophyllide d C-20 methyltransferase.

Gene Ontology

Molecular Function

• GO:0008168 methyltransferase activity
• GO:0008171 O-methyltransferase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0030494 bacteriochlorophyll biosynthetic process
• GO:0032259 methylation
• GO:0036069 light-dependent bacteriochlorophyll biosynthetic process
• GO:0036070 light-independent bacteriochlorophyll biosynthetic process

External links

• PDB: RCSB:1x1c, PDBe:1x1c, PDBj:1x1c
• PDBsum: 1x1c
• PubMed: 16797589
• UniProt: Q8KGE0|BCHU_CHLTE Bacteriochlorophyllide d C-20 methyltransferase (Gene Name=bchU)