Structure of PDB 1wzc Chain A Binding Site BS01

Receptor Information

>1wzc Chain A (length=234) Species: 53953 (Pyrococcus horikoshii)

MIRLIFLDIDKTLIPGYEPDPAKPIIEELKDMGFEIIFNSSKTRAEQEYY
RKELEVETPFISENGSAIFIPKGYFPYIVIELGIRVEKIREELKKLENIY
GLKYYGNSTKEEIEKFTGMPPELVPLAMEREYSETIFEWSRDGWEEVLVE
GGFKVTMGSRFYTVHGNSDKGKAAKILLDFYKRLGQIESYAVGDSYNDFP
MFEVVDKVFIVGSLKHKKAQNVSSIIDVLEVIKH

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 1wzc Chain A Residue 300

Receptor-Ligand Complex Structure

Structure summary

• PDB: 1wzc Structure of mannosyl-3-phosphoglycerate phosphatase from Pyrococcus horikoshii.
• Resolution: 1.9 Å
• Binding residue (original residue number in PDB): D8 D10 S169 D204
• Binding residue (residue number reindexed from 1): D8 D10 S159 D194
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 3.1.3.70: mannosyl-3-phosphoglycerate phosphatase.

Gene Ontology

Molecular Function

• GO:0000287 magnesium ion binding
• GO:0003824 catalytic activity
• GO:0016787 hydrolase activity
• GO:0016791 phosphatase activity
• GO:0046872 metal ion binding
• GO:0050531 mannosyl-3-phosphoglycerate phosphatase activity

Biological Process

• GO:0051479 mannosylglycerate biosynthetic process

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol

External links

• PDB: RCSB:1wzc, PDBe:1wzc, PDBj:1wzc
• PDBsum: 1wzc
• PubMed: 19018103
• UniProt: O58690|MPGP_PYRHO Mannosyl-3-phosphoglycerate phosphatase (Gene Name=mngB)