Structure of PDB 1wlj Chain A Binding Site BS01

Receptor Information
>1wlj Chain A (length=168) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EVVAMDCEMVGLGPHRESGLARCSLVNVHGAVLYDKFIRPEGEITDYRTR
VSGVTPQHMVGATPFAVARLEILQLLKGKLVVGHDLKHDFQALKEDMSGY
TIYDTSTDRLLWREAKLVSLRVLSERLLHKSIQNSLLGHSSVEDARATME
LYQISQRIRARRGLPRLA
Ligand information
Ligand IDMN
InChIInChI=1S/Mn/q+2
InChIKeyWAEMQWOKJMHJLA-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mn+2]
CACTVS 3.341[Mn++]
FormulaMn
NameMANGANESE (II) ION
ChEMBL
DrugBankDB06757
ZINC
PDB chain1wlj Chain A Residue 200 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1wlj Crystal structure of human ISG20, an interferon-induced antiviral ribonuclease
Resolution1.9 Å
Binding residue
(original residue number in PDB)		D11 E13 D154
Binding residue
(residue number reindexed from 1)		D6 E8 D144
Annotation score4
Enzymatic activity
Enzyme Commision number 3.1.13.1: exoribonuclease II.
Gene Ontology
Molecular Function
GO:0000175 3'-5'-RNA exonuclease activity
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0004527 exonuclease activity
GO:0008310 single-stranded DNA 3'-5' DNA exonuclease activity
GO:0008859 exoribonuclease II activity
GO:0030619 U1 snRNA binding
GO:0030620 U2 snRNA binding
GO:0034511 U3 snoRNA binding
GO:0046872 metal ion binding
Biological Process
GO:0006308 DNA catabolic process
GO:0006364 rRNA processing
GO:0006401 RNA catabolic process
GO:0009615 response to virus
GO:0045071 negative regulation of viral genome replication
GO:0045087 innate immune response
GO:0051607 defense response to virus
Cellular Component
GO:0000932 P-body
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0015030 Cajal body
GO:0016605 PML body

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1wlj, PDBe:1wlj, PDBj:1wlj
PDBsum1wlj
PubMed15527770
UniProtQ96AZ6|ISG20_HUMAN Interferon-stimulated gene 20 kDa protein (Gene Name=ISG20)

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