Structure of PDB 1wbp Chain A Binding Site BS01

Receptor Information
>1wbp Chain A (length=350) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
YHLVKIGDLFNGRYHVIRKLGWGHFSTVWLSWDIQGKKFVAMKVVKSAEH
YTETALDEIRLLKSVRNSDPNDPNREMVVQLLDDFKISGVNGTHICMVFE
VLGHHLLKWIIKSNYQGLPLPCVKKIIQQVLQGLDYLHTKCRIIHTDIKP
ENILLSVNEQYIRRLAAEATENFLVNPLEPKNAEKLKVKIADLGNACWVH
KHFTEDIQTRQYRSLEVLIGSGYNTPADIWSTACMAFELATGDYLFEPHS
GEEYTRDEDHIALIIELLGKVPRKLIVAGKYSKEFFTKKGDLKHITKLKP
WGLFEVLVEKYEWSQEEAAGFTDFLLPMLELIPEKRATAAECLRHPWLNS
Ligand information
Receptor-Ligand Complex Structure
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PDB1wbp Interplay between Srpk and Clk/Sty Kinases in Phosphorylation of the Splicing Factor Asf/Sf2 is Regulated by a Docking Motif in Asf/Sf2
Resolution2.4 Å
Binding residue
(original residue number in PDB)		T546 D548 L550 D564 E571 K604 W606 K615 Y616
Binding residue
(residue number reindexed from 1)		T241 D243 L245 D259 E266 K299 W301 K310 Y311
Enzymatic activity
Catalytic site (original residue number in PDB) D213
Catalytic site (residue number reindexed from 1) D147
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:1wbp, PDBe:1wbp, PDBj:1wbp
PDBsum1wbp
PubMed16209947
UniProtQ96SB4|SRPK1_HUMAN SRSF protein kinase 1 (Gene Name=SRPK1)

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