Structure of PDB 1w9k Chain A Binding Site BS01

Receptor Information
>1w9k Chain A (length=719) Species: 44689 (Dictyostelium discoideum) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DPIHDRTSDYHKYLKVKQGDDKRYIWYNPDPKERDSYECGEIVSETSDSF
TFKTVDGQDRQVKKDDANQRNPIKFDGVEDMSELSYLNEPAVFHNLRVRY
NQDLIYTYSGLFLVAVNPFKRIPIYTQEMVDIFKGRRRNEVAPHIFAISD
VAYRSMLDDRQNQSLLITGESGAGKTENTKKVIQYLASVAGRGVLEQQIL
QANPILEAFGNAKTTRNNNSSRFGKFIEIQFNSAGFISGASIQSYLLEKS
RVVFQSETERNYHIFYQLLAGATAEEKKALHLAGPESFNYLNQSGCVDIK
GVSDSEEFKITRQAMDIVGFSQEEQMSIFKIIAGILHLGNIKFEKGAGEG
AVLKDKTALNAASTVFGVNPSVLEKALMEPRILAGRDLVAQHLNVEKSSS
SRDALVKALYGRLFLWLVKKINNVLCEERKAYFIGVLDIEGFEIFKVNSF
EQLCINYTNEKLQQFFNHHMFKLEQEEYLKEKINWTFIDFGLDSQATIDL
IDGRQPPGILALLDEQSVFPNATDNTLITKLHSHFSKKNAKYEEPRFSKT
EFGVTHYAGQVMYEIQDWLEKNKDPLQQDLELCFKDSSDNVVTKLFNDPN
IASRAKFITVAAQYKEQLASLMATLETTNPHFVRCIIPNNKQLPAKLEDK
VVLDQLRCNGVLEGIRITRKGFPNRIIYADFVKEDSQKATDAVLKHLDPE
QFRFGITKIFFRAGQLARI
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain1w9k Chain A Residue 1755 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB1w9k Structure-Function Analysis of Myosin II Backdoor Mutants
Resolution2.05 Å
Binding residue
(original residue number in PDB)		T186 S237
Binding residue
(residue number reindexed from 1)		T176 S221
Annotation score4
Enzymatic activity
Catalytic site (original residue number in PDB) S181 G182 T186 N233 S236 S237 G457 E459
Catalytic site (residue number reindexed from 1) S171 G172 T176 N217 S220 S221 G441 E443
Enzyme Commision number 3.6.4.1: Transferred entry: 5.6.1.8.
Gene Ontology
Molecular Function
GO:0003774 cytoskeletal motor activity
GO:0005524 ATP binding
GO:0051015 actin filament binding
Cellular Component
GO:0016459 myosin complex

View graph for
Molecular Function
View graph for
Cellular Component
External links
PDB RCSB:1w9k, PDBe:1w9k, PDBj:1w9k
PDBsum1w9k
PubMed
UniProtP08799|MYS2_DICDI Myosin-2 heavy chain (Gene Name=mhcA)

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