Structure of PDB 1w6t Chain A Binding Site BS01

Receptor Information
>1w6t Chain A (length=428) Species: 170187 (Streptococcus pneumoniae TIGR4) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HMSIITDVYAREVLDSRGNPTLEVEVYTESGAFGRGMVPSGGEHEAVELR
DGDKSRYGGLGTQKAVDNVNNIIAEAIIGYDVRDQQAIDRAMIALDGTPN
KGKLGANAILGVSIAVARAAADYLEIPLYSYLGGFNTKVLPTPMMNIING
GSHSDAPIAFQEFMILPVGAPTFKEALRYGAEIFHALKKILKSRGLETAV
GDEGGFAPRFEGTEDGVETILAAIEAAGYVPGKDVFLGFDCASSEFYDRK
VYDYTKFEGEGAAVRTSAEQIDYLEELVNKYPIITIEDGMDENDWDGWKA
LTERLGKKVQLVGDDFFVTNTDYLARGIQEGAANSILIKVNQIGTLTETF
EAIEMAKEAGYTAVVSHRSGETEDSTIADIAVATNAGQIKTGSLSRTDRI
AKYNQLLRIEDQLGEVAEYRGLKSFYNL
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain1w6t Chain A Residue 435 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB1w6t Plasmin(Ogen)-Binding Alpha-Enolase from Streptococcus Pneumoniae: Crystal Structure and Evaluation of Plasmin(Ogen)-Binding Sites
Resolution2.1 Å
Binding residue
(original residue number in PDB)		D242 E291 D318
Binding residue
(residue number reindexed from 1)		D240 E287 D314
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) H155 E164 E205 D242 E291 D318 K343 H371 K394
Catalytic site (residue number reindexed from 1) H153 E162 E203 D240 E287 D314 K339 H367 K390
Enzyme Commision number 4.2.1.11: phosphopyruvate hydratase.
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0004634 phosphopyruvate hydratase activity
GO:0005515 protein binding
GO:0016829 lyase activity
GO:0046872 metal ion binding
Biological Process
GO:0006096 glycolytic process
GO:0007155 cell adhesion
Cellular Component
GO:0000015 phosphopyruvate hydratase complex
GO:0005576 extracellular region
GO:0005737 cytoplasm
GO:0009274 peptidoglycan-based cell wall
GO:0009986 cell surface
GO:0042603 capsule

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:1w6t, PDBe:1w6t, PDBj:1w6t
PDBsum1w6t
PubMed15476816
UniProtQ97QS2|ENO_STRPN Enolase (Gene Name=eno)

[Back to BioLiP]