Structure of PDB 1w5o Chain A Binding Site BS01

Receptor Information
>1w5o Chain A (length=329) Species: 208964 (Pseudomonas aeruginosa PAO1) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NRAYPYTRLRRNRRDDFSRRLVRENVLTVDDLILPVFVLDGVNQRESIPS
MPGVERLSIDQLLIEAEEWVALGIPALALFPVTPVEKKSLDAAEAYNPEG
IAQRATRALRERFPELGIITDVCLCPFTTHGQCGILDDDGYVLNDVSIDV
LVRQALSHAEAGAQVVAPSDMMDGRIGAIREALESAGHTNVRVMAYSAKY
ASAYYGPFRDAVGSASNLGKGNKATYQMDPANSDEALHEVAADLAEGADM
VMVKPGMPYLDIVRRVKDEFRAPTFVYQVSGEYAMHMGAIQNGWLAESVI
LESLTAFKRAGADGILTYFAKQAAEQLRR
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain1w5o Chain A Residue 1339 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1w5o Tracking the Evolution of Porphobilinogen Synthase Metal Dependence in Vitro
Resolution1.85 Å
Binding residue
(original residue number in PDB)		C129 C131 C139
Binding residue
(residue number reindexed from 1)		C123 C125 C133
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) K205 K260
Catalytic site (residue number reindexed from 1) K199 K254
Enzyme Commision number 4.2.1.24: porphobilinogen synthase.
Gene Ontology
Molecular Function
GO:0004655 porphobilinogen synthase activity
GO:0008270 zinc ion binding
GO:0016829 lyase activity
GO:0046872 metal ion binding
Biological Process
GO:0006779 porphyrin-containing compound biosynthetic process
GO:0006782 protoporphyrinogen IX biosynthetic process
GO:0006783 heme biosynthetic process
GO:0033014 tetrapyrrole biosynthetic process
Cellular Component
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1w5o, PDBe:1w5o, PDBj:1w5o
PDBsum1w5o
PubMed15644204
UniProtQ59643|HEM2_PSEAE Delta-aminolevulinic acid dehydratase (Gene Name=hemB)

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