Structure of PDB 1w3w Chain A Binding Site BS01

Receptor Information
>1w3w Chain A (length=311) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SSSHFNPDPDAETLYKAMKGIGTNEQAIIDVLTKRSNTQRQQIAKSFKAQ
FGKDLTETLKSELSGKFERLIVALMYPPYRYEAKELHDAMKGLGTKEGVI
IEILASRTKNQLREIMKAYEEDYGSSLEEDIQADTSGYLERILVCLLQGS
RDDVSSFVDPALALQDAQDLYAAGEKIRGTDEMKFITILCTRSATHLLRV
FEEYEKIANKSIEDSIKSETHGSLEEAMLTVVKCTQNLHSYFAERLYYAM
KGAGTRDGTLIRNIVSRSEIDLNLIKCHFKKMYGKTLSSMIMEDTSGDYK
NALLSLVGSDP
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain1w3w Chain A Residue 1328 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB1w3w The Crystal Structure of Annexin A8 is Similar to that of Annexin A3
Resolution1.99 Å
Binding residue
(original residue number in PDB)		M266 G268 G270 D310
Binding residue
(residue number reindexed from 1)		M250 G252 G254 D294
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0001786 phosphatidylserine binding
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0005544 calcium-dependent phospholipid binding
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding
GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding
GO:0043325 phosphatidylinositol-3,4-bisphosphate binding
GO:0046872 metal ion binding
GO:0051015 actin filament binding
Biological Process
GO:0007032 endosome organization
GO:0007596 blood coagulation
GO:0016197 endosomal transport
GO:1900004 negative regulation of serine-type endopeptidase activity
GO:1900138 negative regulation of phospholipase A2 activity
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0012506 vesicle membrane
GO:0031902 late endosome membrane
GO:0042383 sarcolemma
GO:0062023 collagen-containing extracellular matrix

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1w3w, PDBe:1w3w, PDBj:1w3w
PDBsum1w3w
PubMed15644210
UniProtP13928|ANXA8_HUMAN Annexin A8 (Gene Name=ANXA8)

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