Structure of PDB 1w3u Chain A Binding Site BS01

Receptor Information
>1w3u Chain A (length=360) Species: 1397 (Niallia circulans) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ERAYNFNAGPAALPLEVLERAQAEFVDYQHTGMSIMEMSHRGAVYEAVHN
EAQARLLALLGNPTGYKVLFIQGGASTQFAMIPMNFLKEGQTANYVMTGS
WASKALKEAKLIGDTHVAASSEASNYMTLPKLQEIQLQDNAAYLHLTSNE
TIEGAQFKAFPDTGSVPLIGDMSSDILSRPFDLNQFGLVYAGAQKNLGPS
GVTVVIVREDLVAESPKHLPTMLRYDTYVKNNSLYNTPPSFGIYMVNEVL
KWIEERGGLEGVQQANRKKASLIYDAIDQSGGFYRGCVDVDSRSDMNITF
RLASEELEKEFVKASEQEGFVGLKGHRSVGGLRASIYNAVPYESCEALVQ
FMEHFKRSRG
Ligand information
Ligand IDPLP
InChIInChI=1S/C8H10NO6P/c1-5-8(11)7(3-10)6(2-9-5)4-15-16(12,13)14/h2-3,11H,4H2,1H3,(H2,12,13,14)
InChIKeyNGVDGCNFYWLIFO-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341Cc1ncc(CO[P](O)(O)=O)c(C=O)c1O
OpenEye OEToolkits 1.5.0Cc1c(c(c(cn1)COP(=O)(O)O)C=O)O
ACDLabs 10.04O=P(O)(O)OCc1cnc(c(O)c1C=O)C
FormulaC8 H10 N O6 P
NamePYRIDOXAL-5'-PHOSPHATE;
VITAMIN B6 Phosphate
ChEMBLCHEMBL82202
DrugBankDB00114
ZINCZINC000001532514
PDB chain1w3u Chain A Residue 1363 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1w3u Enzyme Adaptation to Alkaline Ph: Atomic Resolution (1.08 A) Structure of Phosphoserine Aminotransferase from Bacillus Alcalophilus
Resolution1.5 Å
Binding residue
(original residue number in PDB)		G76 A77 S78 W103 T153 D173 S175 Q196 K197
Binding residue
(residue number reindexed from 1)		G74 A75 S76 W101 T151 D171 S173 Q194 K195
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) W103 D173 K197
Catalytic site (residue number reindexed from 1) W101 D171 K195
Enzyme Commision number 2.6.1.52: phosphoserine transaminase.
Gene Ontology
Molecular Function
GO:0004648 O-phospho-L-serine:2-oxoglutarate aminotransferase activity
GO:0008483 transaminase activity
GO:0030170 pyridoxal phosphate binding
Biological Process
GO:0006563 L-serine metabolic process
GO:0006564 L-serine biosynthetic process
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1w3u, PDBe:1w3u, PDBj:1w3u
PDBsum1w3u
PubMed15608117
UniProtQ59196|SERC_NIACI Phosphoserine aminotransferase (Gene Name=serC)

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