Structure of PDB 1w1z Chain A Binding Site BS01

Receptor Information
>1w1z Chain A (length=319) Species: 1098 (Prosthecochloris vibrioformis) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VHRPRRLRRTAALRNLVQENTLTVNDLVFPLFVMPGTNAVEEVSSMPGSF
RFTIDRAVEECKELYDLGIQGIDLFGIPEQKTEDGSEAYNDNGILQQAIR
AIKKAVPELCIMTDVALDPFTPFGHDGLVKDGIILNDETVEVLQKMAVSH
AEAGADFVSPSDMMDGRIGAIREALDETDHSDVGILSYAAKYASSFYGPF
RDALHSAPQFGDKSTYQMNPANTEEAMKEVELDIVEGADIVMVKPGLAYL
DIVWRTKERFDVPVAIYHVSGEYAMVKAAAAKGWIDEDRVMMESLLCMKR
AGADIIFTYYAKEAAKKLR
Ligand information
Ligand IDSHF
InChIInChI=1S/C5H8O3/c1-4(6)2-3-5(7)8/h2-3H2,1H3,(H,7,8)
InChIKeyJOOXCMJARBKPKM-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.7.6CC(=O)CCC(=O)O
CACTVS 3.370CC(=O)CCC(O)=O
ACDLabs 12.01O=C(C)CCC(=O)O
FormulaC5 H8 O3
NameLAEVULINIC ACID;
LEVULINIC ACID
ChEMBLCHEMBL1235931
DrugBankDB02239
ZINCZINC000000586584
PDB chain1w1z Chain A Residue 1253 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1w1z The X-ray structure of the plant like 5-aminolaevulinic acid dehydratase from Chlorobium vibrioforme complexed with the inhibitor laevulinic acid at 2.6 A resolution.
Resolution2.6 Å
Binding residue
(original residue number in PDB)		F209 K253 Y276 S279 Y318
Binding residue
(residue number reindexed from 1)		F200 K244 Y267 S270 Y309
Annotation score2
Enzymatic activity
Catalytic site (original residue number in PDB) K200 K253
Catalytic site (residue number reindexed from 1) K191 K244
Enzyme Commision number 4.2.1.24: porphobilinogen synthase.
Gene Ontology
Molecular Function
GO:0004655 porphobilinogen synthase activity
GO:0008270 zinc ion binding
GO:0016829 lyase activity
GO:0046872 metal ion binding
Biological Process
GO:0006782 protoporphyrinogen IX biosynthetic process
GO:0006783 heme biosynthetic process
GO:0033014 tetrapyrrole biosynthetic process
Cellular Component
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1w1z, PDBe:1w1z, PDBj:1w1z
PDBsum1w1z
PubMed15327955
UniProtQ59334|HEM2_CHLP8 Delta-aminolevulinic acid dehydratase (Gene Name=hemB)

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